ArticleBMC cancer2009
Mammographic density and epithelial histopathologic markers.
Article in BMC cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.The Journal of clinical investigation · 2020Trial
- Effect of Bazedoxifene and Conjugated Estrogen (Duavee) on Breast Cancer Risk Biomarkers in High-Risk Women: A Pilot Study.Cancer prevention research (Philadelphia, Pa.) · 2019Trial
- Mammographic Breast Density at Breast Cancer Diagnosis and Breast Cancer-Specific Survival.Diagnostics (Basel, Switzerland) · 2024Article
- Association of mammographic and sonographic findings with prognostic molecular factors and hormone receptor expression in malignant breast lesions.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024Article
- Breast tumor tissue inflammation but not lobular involution is associated with survival among breast cancer patients in the Multiethnic Cohort.Cancer epidemiology · 2020Article
- A review of the influence of mammographic density on breast cancer clinical and pathological phenotype.Breast cancer research and treatment · 2019Review
- Mammographic density and breast tissue expression of inflammatory markers, growth factors, and vimentin.BMC cancer · 2018Article
- Review of quantitative multiscale imaging of breast cancer.Journal of medical imaging (Bellingham, Wash.) · 2018Review
- Involution of breast tissue and mammographic density.Breast cancer research : BCR · 2016Article
- High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium.Breast cancer research : BCR · 2015Article
- SEER cancer registry biospecimen research: yesterday and tomorrow.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2014Review
- Parity and expression of epithelial histopathologic markers in breast tissue.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2013Article
- Mammographic breast density response to aromatase inhibition.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Mammographic Density and Prediction of Nodal Status in Breast Cancer Patients.Geburtshilfe und Frauenheilkunde · 2013Article
- No evidence for association of inherited variation in genes involved in mitosis and percent mammographic density.Breast cancer research : BCR · 2012Article
- Tissue composition of mammographically dense and non-dense breast tissue.Breast cancer research and treatment · 2012Article
- Aromatase immunoreactivity is increased in mammographically dense regions of the breast.Breast cancer research and treatment · 2011Article
- Mammographic density and matrix metalloproteinases in breast tissue.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2010Article
- Mammographic density as a predictor of breast cancer outcome.Future oncology (London, England) · 2010Article
- Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density.Breast cancer research : BCR · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWe explored the association of mammographic density, a breast cancer risk factor, with hormonal and proliferation markers in benign tissue from tumor blocks of pre-and postmenopausal breast cancer cases.
methodsBreast cancer cases were recruited from a case-control study on breast density. Mammographic density was assessed on digitized prediagnostic mammograms using a computer-assisted method. For 279 participants of the original study, we obtained tumor blocks and prepared tissue microarrays (TMA), but benign tissue cores were only available for 159 women. The TMAs were immunostained for estrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor (PR), HER2/neu, Ki-67, and Proliferating Cell Nuclear Antigen (PCNA). We applied general linear models to compute breast density according to marker expression.
resultsA substantial proportion of the samples were in the low or no staining categories. None of the results was statistically significant, but women with PR and ERbeta staining had 3.4% and 2.4% higher percent density. The respective values for Caucasians were 5.7% and 11.6% but less in Japanese women (3.5% and -1.1%). Percent density was 3.4% higher in women with any Ki-67 staining and 2.2% in those with positive PCNA staining.
conclusionThis study detected little evidence for an association between mammographic density and expression of steroid receptors and proliferation markers in breast tissue, but it illustrated the problems of locating tumor blocks and benign breast tissue samples for epidemiologic research. Given the suggestive findings, future studies examining estrogen effects in tissue, cell proliferation, and density in the breast may be informative.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.