ArticleAnnals of human genetics2009
Association between SNP heterozygosity and quantitative traits in the Framingham Heart Study.
Article in Annals of human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Revealing modifier variations characterizations for elucidating the genetic basis of human phenotypic variations.Human genetics · 2022Article
- An elucidation of over a century old enigma in genetics-Heterosis.PLoS biology · 2019Article
- Heterozygosity Ratio, a Robust Global Genomic Measure of Autozygosity and Its Association with Height and Disease Risk.Genetics · 2016Article
- Local effects drive heterozygosity-fitness correlations in an outcrossing long-lived tree.Proceedings. Biological sciences · 2015Article
- Multilocus heterozygosity and coronary heart disease: nested case-control studies in men and women.PloS one · 2015Article
- Investigation of individual heterozygosity correlated to growth traits in Tongshan Black-boned goat.Molecular biology reports · 2013Article
- Gene expression analysis of whole blood, peripheral blood mononuclear cells, and lymphoblastoid cell lines from the Framingham Heart Study.Physiological genomics · 2012Article
- The emergence of human-evolutionary medical genomics.Evolutionary applications · 2011Article
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Authors and funding
6 authors.
Funding
Abstract
Associations between multilocus heterozygosity and fitness traits, also termed heterozygosity and fitness correlations (HFCs), have been reported in numerous organisms. These studies, in general, indicate a positive relationship between heterozygosity and fitness traits. We studied the association between genome-wide heterozygosity at 706 non-synonymous and synonymous SNPs and 19 quantitative traits, including morphological, biochemical and fitness traits in the Framingham Heart Study. Statistically significant association was found between heterozygosity and systolic and diastolic blood pressures as well as left ventricular diameter and wall thickness. These results suggest that heterozygosity may be associated with traits, such as blood pressure that closely track environmental variations. Balancing selection may be operating in the maintenance of heterozygosity and the major components of blood pressure and hypertension. Genome wide SNP heterozygosity may be used to understand the phenomenon of dominance as well as the evolutionary basis of many quantitative traits in humans.
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