ArticleAddiction biology2009
FOSB proteins in the orbitofrontal and dorsolateral prefrontal cortices of human alcoholics.
Article in Addiction biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Influence of chronic administration of morphine and its withdrawal on the behaviour of zebrafish.Journal of biosciences · 2023Article
- Perspectives on fronto-fugal circuitry from human imaging of alcohol use disorders.Neuropharmacology · 2017Review
- The Sensitivity of the Crayfish Reward System to Mammalian Drugs of Abuse.Frontiers in physiology · 2017Review
- Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics.Frontiers in cellular neuroscience · 2015Article
- Molecular basis of alcoholism.Handbook of clinical neurology · 2014Review
- Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system.Frontiers in molecular neuroscience · 2012Article
- Transcriptional control of maladaptive and protective responses in alcoholics: a role of the NF-κB system.Brain, behavior, and immunity · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
The transcription factor DeltaFosB is accumulated in the addiction circuitry, including the orbitofrontal and medial prefrontal cortices of rodents chronically exposed to ethanol or other drugs of abuse, and has been suggested to play a direct role in addiction maintenance. To address this hypothesis in the context of substance dependence in humans, we compared the immunoreactivities of FOSB proteins in the orbitofrontal and dorsolateral prefrontal cortices (OFC and DLPFC respectively) between controls and alcoholics using semiquantitative immunoblotting. In both structures, we detected three forms of FOSB, one of which was DeltaFOSB, but in neither case did their immunoreactivities differ between the groups. Our results indicate that the DeltaFOSB immunoreactivity in the human brain is very low, and that it is not accumulated in the OFC and DLPFC of human alcoholics, suggesting that it may not be directly involved in addiction maintenance, at least not in ethanol dependence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.