ArticleMolecular diversity2010
Ionic liquid-promoted multi-component reaction: novel and efficient preparation of pyrazolo[3,4-b]pyridinone, pyrazolo[3,4-b]-quinolinone and their hybrids with pyrimidine nucleoside.
Article in Molecular diversity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Design and Synthesis of New Pyrimidine-Quinolone Hybrids as NovelPharmaceuticals (Basel, Switzerland) · 2022Article
- Pyridine-2-carboxylic acid as an effectual catalyst for rapid multi-component synthesis of pyrazolo[3,4-RSC advances · 2020Article
- Crystal structure of 4,6-di-amino-2-(methyl-sulfan-yl)pyridine-3-carbo-nitrile.Acta crystallographica. Section E, Crystallographic communications · 2015Article
- Multicomponent reactions in nucleoside chemistry.Beilstein journal of organic chemistry · 2014Review
- Diversity oriented syntheses of conventional heterocycles by smart multi component reactions (MCRs) of the last decade.Molecules (Basel, Switzerland) · 2012Review
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Authors and funding
7 authors.
Funding
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Abstract
The utilization of an ionic liquid, [bmim][BF(4)] as both reaction medium and promoter for a multi-component reaction of aldehyde (1) and 5-amino-3-methyl-1-phenylpyrazole (2) with Meldrum acid (3) or dimedone (5) is studied. From this reaction, pyrazolo[3,4-b]pyridinone (4) and pyrazolo[3,4-b]quinolinone (6) derivatives were prepared in high yields. This novel procedure showed such advantages as environmentally benign nature, enhanced efficiency, simple operation process, and mild reaction conditions. As an application, the procedure was successfully used in the preparation of a set of pyrimidine nucleoside-pyrazolo[3,4-b]pyridine and pyrazolo[3,4-b]quinolinone hybrids with potential biological activities.
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Registered trials
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