ReviewHuman genetics2009
Genetics of psychosis; insights from views across the genome.
Review in Human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 3 syntheses or guidelines pooled it, 214 citations in OpenAlex.
- Association between rs1344706 of ZNF804A and schizophrenia: a meta-analysis.Genomics, proteomics & bioinformatics · 2014Pooled it
- Genome-wide association study of Alzheimer's disease with psychotic symptoms.Molecular psychiatry · 2012Pooled it
- Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.Molecular psychiatry · 2012Pooled it
- Social-spatial residence patterns and adolescent mental health: Investigating the influences of residential segregation, neighborhood social cohesion, and race on persistent, distressing psychotic-like experiences in the United States.Social science & medicine (1982) · 2025Article
- Polymorphism in the ZNF804A Gene and Variation in DBiological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Glutamatergic dysfunction in Schizophrenia.Translational psychiatry · 2022Review
- Identification of Rare Mutations of Two Presynaptic Cytomatrix GenesJournal of personalized medicine · 2021Article
- Article
- DNA Methylation Analysis of the NR3C1 Gene in Patients with Schizophrenia.Journal of molecular neuroscience : MN · 2020Article
- Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Article
- Psychiatric Diagnoses and Treatment Preceding Schizophrenia in Adolescents Aged 9-17 Years.Frontiers in psychiatry · 2020Article
- Myt1L Promotes Differentiation of Oligodendrocyte Precursor Cells and is Necessary for Remyelination After Lysolecithin-Induced Demyelination.Neuroscience bulletin · 2018Article
- Non-coding RNA dysregulation in the amygdala region of schizophrenia patients contributes to the pathogenesis of the disease.Translational psychiatry · 2018Article
- Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers.JCI insight · 2017Article
- Attempts to replicate genetic associations with schizophrenia in a cohort from north India.NPJ schizophrenia · 2017Article
- Progressive Decline in Hippocampal CA1 Volume in Individuals at Ultra-High-Risk for Psychosis Who Do Not Remit: Findings from the Longitudinal Youth at Risk Study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Adult Neurogenesis and Psychiatric Disorders.Cold Spring Harbor perspectives in biology · 2016Review
- Individual risk alleles of susceptibility to schizophrenia are associated with poor clinical and social outcomes.Journal of human genetics · 2016Article
- Correspondence of DNA Methylation Between Blood and Brain Tissue and Its Application to Schizophrenia Research.Schizophrenia bulletin · 2016Article
- Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models.Neural plasticity · 2016Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major psychotic illnesses, schizophrenia and bipolar disorder (BD), are among the most heritable common disorders, but finding specific susceptibility genes for them has not been straightforward. The reasons are widely assumed to include lack of valid phenotypic definition, absence of good theories of pathophysiology for candidate gene studies, and the involvement of many genes, each making small contributions to population risk. Within the last year or so, a number of genome wide association (GWAS) of schizophrenia and BD have been published. These have produced stronger evidence for association to specific risk loci than have earlier studies, specifically for the zinc finger binding protein 804A (ZNF804A) locus in schizophrenia and for the calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C) and ankyrin 3, node of Ranvier (ANK3) loci in bipolar disorder. The ZNF804A and CACNA1C loci appear to influence risk for both disorders, a finding that supports the hypothesis that schizophrenia and BD are not aetiologically distinct. In the case of schizophrenia, a number of rare copy number variants have also been detected that have fairly large effect sizes on disease risk, and that additionally influence risk of autism, mental retardation, and other neurodevelopmental disorders. The existing findings point to some likely pathophysiological mechanisms but also challenge current concepts of disease classification. They also provide grounds for optimism that larger studies will reveal more about the origins of these disorders, although currently, very little of the genetic risk of either disorder is explained.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.