ArticleInternational journal of biological sciences2009
Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina.
Article in International journal of biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 111 citations in OpenAlex.
- Exploring Microalgae as a Novel Resource for Hepatocellular Carcinoma Therapy.Molecules (Basel, Switzerland) · 2026Review
- Combining In Vitro, In Vivo, and Network Pharmacology Assays to Identify Targets and Molecular Mechanisms of Spirulina-Derived Biomolecules against Breast Cancer.Marine drugs · 2024Article
- Spirulina supplementation to alleviate negative effects of lead in layer chicken.Journal of advanced veterinary and animal research · 2023Article
- Growth, carcass criteria, and blood biochemical parameters of growing quails fed Arthrospira platensis as a feed additive.Poultry science · 2023Article
- The Effects of DietaryAnimals : an open access journal from MDPI · 2023Article
- Effect of Dietary Blue-Green Microalgae Inclusion as a Replacement to Soybean Meal on Laying Hens' Performance, Egg Quality, Plasma Metabolites, and Hematology.Animals : an open access journal from MDPI · 2022Article
- Hypocholesterolemic, Antioxidative, and Anti-Inflammatory Effects of DietaryAnimals : an open access journal from MDPI · 2022Article
- The chemoprevention of spirulina platensis and garlic against diethylnitrosamine induced liver cancer in rats via amelioration of inflammatory cytokines expression and oxidative stress.Toxicology research · 2022Article
- Impact of tumor-parenchyma biomechanics on liver metastatic progression: a multi-model approach.Scientific reports · 2021Article
- Hepatosplenic Protective Actions ofFrontiers in veterinary science · 2021Article
- Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats.Analytical cellular pathology (Amsterdam) · 2019Article
- Arthrospira Platensis - Potential in Dermatology and Beyond.Open access Macedonian journal of medical sciences · 2018Review
- Article
- Hypolipidemic effect and activation of Lecithin Cholesterol Acyl Transferase (LCAT) by aqueous extract ofBMC nutrition · 2017Article
- Multiscale computational model of fluid flow and matrix deformation in decellularized liver.Journal of the mechanical behavior of biomedical materials · 2016Article
- Antioxidant Potential of Spirulina platensis Mitigates Oxidative Stress and Reprotoxicity Induced by Sodium Arsenite in Male Rats.Oxidative medicine and cellular longevity · 2016Article
- Cultivation ofJournal, genetic engineering & biotechnology · 2015Article
- Inhibitory Effect of Spirulina maxima on the Azoxymethane-induced Aberrant Colon Crypts and Oxidative Damage in Mice.Pharmacognosy magazine · 2015Article
- Spirulina platensis Lacks Antitumor Effect against Solid Ehrlich Carcinoma in Female Mice.Advances in pharmacological sciences · 2015Article
- Inhibitory effects of dietary Spirulina platensis on UVB-induced skin inflammatory responses and carcinogenesis.The Journal of investigative dermatology · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spirulina platensis (SP) is a filamentous cyanobacterium microalgae with potent dietary phyto-antioxidant, anti-inflammatory and anti-cancerous properties. The present study aimed to investigate the chemopreventive effect of SP against rat liver toxicity and carcinogenesis induced by dibutyl nitrosamine (DBN) precursors, and further characterized its underlying mechanisms of action in HepG2 cell line. Investigation by light and electron microscopy showed that DBN treatment induced severe liver injury and histopathological abnormalities, which were prevented by SP supplementation. The incidence of liver tumors was significantly reduced from 80 to 20% by SP. Immunohistochemical results indicated that both PCNA and p53 were highly expressed in the liver of DBN-treated rats, but were significantly reduced by SP supplementation. Molecular analysis indicated that SP treatment inhibited cell proliferation, which was accompanied by increased p21 and decreased Rb expression levels at 48hrs post-treatment. In addition, SP increased Bax and decreased Bcl-2 expression, indicating induction of apoptosis by 48hrs. This is the first report of the in vivo chemopreventive effect of SP against DBN-induced rat liver cytotoxicity and carcinogenesis, suggesting its potential use in chemoprevention of cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.