ArticlePloS one2009
Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
34 citing papers in PubMed, 55 citations in OpenAlex.
- Reduced contextually induced muscle thermogenesis in rats with calorie restriction and lower aerobic fitness but not monogenic obesity.Temperature (Austin, Tex.) · 2023Article
- Altered skeletal muscle sarco-endoplasmic reticulum CaAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Intrinsic exercise capacity induces divergent vascular plasticity via arachidonic acid-mediated inflammatory pathways in female rats.Vascular pharmacology · 2021Article
- Effects of early-life exposure to Western diet and voluntary exercise on adult activity levels, exercise physiology, and associated traits in selectively bred High Runner mice.Physiology & behavior · 2021Article
- Enhanced weight and fat loss from long-term intermittent fasting in obesity-prone, low-fitness rats.Physiology & behavior · 2021Article
- Intrinsic Exercise Capacity and Mitochondrial DNA Lead to Opposing Vascular-Associated Risks.Function (Oxford, England) · 2021Article
- Night Migratory Songbirds Exhibit Metabolic Ability to Support High Aerobic Capacity during Migration.ACS omega · 2020Article
- Aerobic capacity modulates adaptive thermogenesis: Contribution of non-resting energy expenditure.Physiology & behavior · 2020Article
- Distribution of allele frequencies for genes associated with physical activity and/or physical capacity in a homogenous Norwegian cohort- a cross-sectional study.BMC genetics · 2020Article
- Physiological and Biochemical Effects of Intrinsically High and Low Exercise Capacities Through Multiomics Approaches.Frontiers in physiology · 2019Article
- Inherently Lean Rats Have Enhanced Activity and Skeletal Muscle Response to Central Melanocortin Receptors.Obesity (Silver Spring, Md.) · 2018Article
- Acclimation to hypoxia increases carbohydrate use during exercise in high-altitude deer mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Metabolic risk factors in mice divergently selected for BMR fed high fat and high carb diets.PloS one · 2017Article
- Ventromedial hypothalamic melanocortin receptor activation: regulation of activity energy expenditure and skeletal muscle thermogenesis.The Journal of physiology · 2016Article
- Reprogramming of energy metabolism as a driver of aging.Oncotarget · 2016Review
- c.A2456C-substitution in Pck1 changes the enzyme kinetic and functional properties modifying fat distribution in pigs.Scientific reports · 2016Article
- Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans.The Journal of biological chemistry · 2016Article
- Are Older Adults Physically Active Enough - A Matter of Assessment Method? The Generation 100 Study.PloS one · 2016Article
- Contribution of regional brain melanocortin receptor subtypes to elevated activity energy expenditure in lean, active rats.Neuroscience · 2015Article
- Physically active rats lose more weight during calorie restriction.Physiology & behavior · 2015Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Some people remain lean despite pressure to gain weight. Lean people tend to have high daily activity levels, but the source of this increased activity is unknown. We found that leanness cannot be accounted for by increased weight-corrected food intake in two different types of lean rats. As previously reported in lean people, we found that lean rats had higher daily activity levels; lean rats also expended more energy. These lean rats were developed through artificial selection for high aerobic endurance capacity. To test whether our findings extended to a human population, we measured endurance capacity using a VO(2max) treadmill test and daily activity in a group of non-exercising individuals. Similar to lean rats selectively bred for endurance capacity, our study revealed that people with higher VO(2max) also spent more time active throughout the day. Hence, endurance capacity may be the trait that underlies both physical activity levels and leanness. We identified one potential mechanism for the lean, active phenotype in rats, namely high levels of skeletal muscle PEPCK. Therefore, the lean phenotype is characterized by high endurance capacity and high activity and may stem from altered skeletal muscle energetics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.