ArticlePLoS genetics2009
Complex adaptations can drive the evolution of the capacitor [PSI], even with realistic rates of yeast sex.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Article
- The effect of mutational robustness on the evolvability of multicellular organisms and eukaryotic cells.Journal of evolutionary biology · 2023Article
- Do Transgenerational Epigenetic Inheritance and Immune System Development Share Common Epigenetic Processes?Journal of developmental biology · 2021Review
- Protein self-assembly: A new frontier in cell signaling.Current opinion in cell biology · 2021Review
- Protein assembly systems in natural and synthetic biology.BMC biology · 2020Review
- A Non-amyloid Prion Particle that Activates a Heritable Gene Expression Program.Molecular cell · 2020Article
- The causes of evolvability and their evolution.Nature reviews. Genetics · 2019Review
- More than Just a Phase: Prions at the Crossroads of Epigenetic Inheritance and Evolutionary Change.Journal of molecular biology · 2018Review
- Epigenetic inheritance, prions and evolution.Journal of genetics · 2017Review
- Mistranslation can enhance fitness through purging of deleterious mutations.Nature communications · 2017Article
- Article
- Article
- Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.Nucleic acids research · 2016Review
- On the Nature and Evolutionary Impact of Phenotypic Robustness Mechanisms.Annual review of ecology, evolution, and systematics · 2014Article
- Article
- Rebels with a cause: molecular features and physiological consequences of yeast prions.FEMS yeast research · 2014Review
- Q&A: Evolutionary capacitance.BMC biology · 2013Article
- Compensatory evolution and the origins of innovations.Genetics · 2013Article
- Article
- Prions in yeast.Genetics · 2012Review
Corrections and comments
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Authors and funding
2 authors.
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Abstract
The [PSI(+)] prion may enhance evolvability by revealing previously cryptic genetic variation, but it is unclear whether such evolvability properties could be favored by natural selection. Sex inhibits the evolution of other putative evolvability mechanisms, such as mutator alleles. This paper explores whether sex also prevents natural selection from favoring modifier alleles that facilitate [PSI(+)] formation. Sex may permit the spread of "cheater" alleles that acquire the benefits of [PSI(+)] through mating without incurring the cost of producing [PSI(+)] at times when it is not adaptive. Using recent quantitative estimates of the frequency of sex in Saccharomyces paradoxus, we calculate that natural selection for evolvability can drive the evolution of the [PSI(+)] system, so long as yeast populations occasionally require complex adaptations involving synergistic epistasis between two loci. If adaptations are always simple and require substitution at only a single locus, then the [PSI(+)] system is not favored by natural selection. Obligate sex might inhibit the evolution of [PSI(+)]-like systems in other species.
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