ArticleHuman heredity2009
Mother's genome or maternally-inherited genes acting in the fetus influence gestational age in familial preterm birth.
Article in Human heredity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci.PLoS genetics · 2023Pooled it
- Finding lost genes in GWAS via integrative-omics analysis reveals novel sub-networks associated with preterm birth.Human molecular genetics · 2016Pooled it
- Effect of interleukin-6 polymorphism on risk of preterm birth within population strata: a meta-analysis.BMC genetics · 2013Pooled it
- The heritability of gestational age in a two-million member cohort: implications for spontaneous preterm birth.Human genetics · 2015Trial
- Presumed etiology of preterm birth: brain injury and neurodevelopmental outcomes.Pediatric research · 2025Article
- Mapping genetic susceptibility to spontaneous preterm birth: analysis of Utah pedigrees to find inherited genetic factors.American journal of obstetrics and gynecology · 2025Article
- Broadening the paradigm of laminin α2-related muscular dystrophy: A case of partial merosin deficiency with compound heterozygous variants.SAGE open medical case reports · 2025Article
- Maternal-fetal conflict and the timing of birth.Evolution, medicine, and public health · 2025Review
- Barrier genes are associated with preterm birth.Frontiers in medicine · 2025Article
- Recent Advances in Genomic Studies of Gestational Duration and Preterm Birth.Clinics in perinatology · 2024Review
- Genetic variants associated with spontaneous preterm birth in women from India: a prospective cohort study.The Lancet regional health. Southeast Asia · 2023Article
- Genetics, epigenetics, and transcriptomics of preterm birth.American journal of reproductive immunology (New York, N.Y. : 1989) · 2022Review
- Identification of a novel gene signature in second-trimester amniotic fluid for the prediction of preterm birth.Scientific reports · 2022Article
- Study protocol to quantify the genetic architecture of sonographic cervical length and its relationship to spontaneous preterm birth.BMJ open · 2022Article
- Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: a review.Environmental health and preventive medicine · 2022Review
- Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes.NPJ genomic medicine · 2021Review
- Developing a theoretical evolutionary framework to solve the mystery of parturition initiation.eLife · 2020Review
- Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci.Nature communications · 2020Article
- Recent advances in the genetics of preterm birth.Annals of human genetics · 2020Review
- Genomic and molecular characterization of preterm birth.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
Corrections and comments
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Authors and funding
21 authors.
Funding
Abstract
objectiveWhile multiple lines of evidence suggest the importance of genetic contributors to risk of preterm birth, the nature of the genetic component has not been identified. We perform segregation analyses to identify the best fitting genetic model for gestational age, a quantitative proxy for preterm birth.
methodsBecause either mother or infant can be considered the proband from a preterm delivery and there is evidence to suggest that genetic factors in either one or both may influence the trait, we performed segregation analysis for gestational age either attributed to the infant (infant's gestational age), or the mother (by averaging the gestational ages at which her children were delivered), using 96 multiplex preterm families.
resultsThese data lend further support to a genetic component contributing to birth timing since sporadic (i.e. no familial resemblance) and nontransmission (i.e. environmental factors alone contribute to gestational age) models are strongly rejected. Analyses of gestational age attributed to the infant support a model in which mother's genome and/or maternally-inherited genes acting in the fetus are largely responsible for birth timing, with a smaller contribution from the paternally-inherited alleles in the fetal genome.
conclusionOur findings suggest that genetic influences on birth timing are important and likely complex.
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