ArticleAmerican journal of respiratory cell and molecular biology2010
Inhibition of Pyk2 blocks airway inflammation and hyperresponsiveness in a mouse model of asthma.
Article in American journal of respiratory cell and molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Pharmacological Inhibition of FAK-Pyk2 Pathway Protects Against Organ Damage and Prolongs the Survival of Septic Mice.Frontiers in immunology · 2022Article
- Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation.Nature communications · 2021Article
- TAT delivery of a PTEN peptide inhibitor has direct cardioprotective effects and improves outcomes in rodent models of cardiac arrest.American journal of physiology. Heart and circulatory physiology · 2021Article
- Two macrophages, osteoclasts and microglia: from development to pleiotropy.Bone research · 2021Review
- Expression of vitamin D receptor in bronchial asthma and its bioinformatics prediction.Molecular medicine reports · 2018Article
- Review
- CF airway smooth muscle transcriptome reveals a role for PYK2.JCI insight · 2017Article
- HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability.BMC neuroscience · 2014Article
- Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease.Oncoscience · 2014Article
- Functions of NOD-Like Receptors in Human Diseases.Frontiers in immunology · 2013Review
- Distinct role of Pyk2 in mediating thromboxane generation downstream of both G12/13 and integrin αIIbβ3 in platelets.The Journal of biological chemistry · 2013Article
- A network-based systematic study for the mechanism of the treatment of zhengs related to cough variant asthma.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Iloprost improves endothelial barrier function in lipopolysaccharide-induced lung injury.The European respiratory journal · 2013Article
- Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.The Journal of biological chemistry · 2012Article
- Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury.Respiratory research · 2012Article
- Focal adhesion kinases in adhesion structures and disease.Journal of signal transduction · 2012Article
- Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation.The Journal of biological chemistry · 2011Article
- Hematopoietic Pyk2 regulates migration of differentiated HL-60 cells.Journal of inflammation (London, England) · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The objective of this investigation was to determine the role of Pyk2, an intracellular nonreceptor protein tyrosine kinase for postadhesive inflammatory cell migration, on airway inflammation and hyperresponsiveness in immune-sensitized mice. Blockade of Pyk2 was effected by intraperitoneal administration of dominant-negative C-terminal Pyk2 fused to a TAT protein transduction domain (TAT-Pyk2-CT). Ovalbumin challenge elicited infiltration of both eosinophils and lymphocytes into airways, increased mucus-containing epithelial cells, and caused increased airway hyperresponsiveness to methacholine in immune-sensitized mice. Pretreatment with 10 mg/kg TAT-Pyk2-CT intraperitoneally blocked all of these effects and further decreased secretion of Th2 cytokine IL-4, IL-5, and IL-13 into the bronchoalveolar lavage fluid. Intranasal administration of IL-5 caused eosinophil migration into the airway lumen, which was attenuated by systemic pretreatment with TAT-Pyk2-CT. In each paradigm, treatment with control protein TAT-GFP had no blocking effect. We conclude that Pyk2, which is essential for inflammatory cell migration in vitro, regulates airway inflammation, Th2 cytokine secretion, and airway hyperresponsiveness in the ovalbumin-sensitized mice during antigen challenge in vivo.
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