ArticleAmerican journal of respiratory and critical care medicine2009
Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema.
Article in American journal of respiratory and critical care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Chronic Hypobaric Hypoxia at High Altitudes Aggravates Chronic Obstructive Pulmonary Disease in Mice.Journal of inflammation research · 2026Article
- Serum neuropilin-1 level may predict airway remodeling based on age and smoking status in asthma.Asia Pacific allergy · 2025Article
- Bronchopulmonary dysplasia with pulmonary hypertension associates with semaphorin signaling loss and functionally decreased FOXF1 expression.Nature communications · 2025Article
- Article
- Neutrophil Elastase Targets Select Proteins on Human Blood-Monocyte-Derived Macrophage Cell Surfaces.International journal of molecular sciences · 2024Article
- Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection.Molecular medicine (Cambridge, Mass.) · 2021Review
- Neuropilin-1 and platelet-derived growth factor receptors cooperatively regulate intermediate filaments and mesenchymal cell migration during alveolar septation.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- VEGF (Vascular Endothelial Growth Factor) and Fibrotic Lung Disease.International journal of molecular sciences · 2018Review
- Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF).Respiratory research · 2018Article
- Article
- Lymphangiogenesis and metastasis--a closer look at the neuropilin/semaphorin3 axis.Microvascular research · 2014Review
- Aquaporin 5 regulates cigarette smoke induced emphysema by modulating barrier and immune properties of the epithelium.Tissue barriers · 2013Article
- Expression of semaphorin 3A and neuropilin 1 in asthma.Journal of Korean medical science · 2013Article
- Vascular endothelial growth factor A promotes vaccinia virus entry into host cells via activation of the Akt pathway.Journal of virology · 2013Article
- Article
- Neuropilins: expression and roles in the epithelium.International journal of experimental pathology · 2012Review
- Interleukin-6 mediates pulmonary vascular permeability in a two-hit model of ventilator-associated lung injury.Experimental lung research · 2011Article
- Involvement of ceramide in cell death responses in the pulmonary circulation.Proceedings of the American Thoracic Society · 2011Review
- Stress responses affecting homeostasis of the alveolar capillary unit.Proceedings of the American Thoracic Society · 2011Review
- Semaphorin 3A contributes to distal pulmonary epithelial cell differentiation and lung morphogenesis.PloS one · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleCigarette smoke (CS) exposure is an important risk factor for chronic obstructive pulmonary disease; however, not all smokers develop disease, suggesting that other factors influence disease development.
objectivesWe sought to determine whether neuropilin-1 (Nrp1), an integral component of receptor complexes mediating alveolar septation and vascular development, was involved in maintenance of normal alveolar structure, and/or altered susceptibility to the effects of CS.
methodsTransgenic mice were generated to achieve inducible lung-specific deletion of epithelial Nrp1. We determined whether conditional Nrp1 deletion altered airspace size, then compared the effects of chronic CS or filtered air exposure on airspace size, inflammation, and the balance between cell death and proliferation in conditionally Nrp1-deficient adult mice and littermate controls. Finally, we evaluated the effects of Nrp1 silencing on cell death after acute exposure of A549 cells to cigarette smoke extract or short chain ceramides. MEASUREMENTS AND MAIN
resultsGenetic deletion of epithelial Nrp1 in either postnatal or adult lungs resulted in a small increase in airspace size. More notably, both airspace enlargement and apoptosis of type I and type II alveolar epithelial cells were significantly enhanced following chronic CS exposure in conditionally Nrp1-deficient adult mice. Silencing of Nrp1 in A549 cells did not alter cell survival after vehicle treatment but significantly augmented apoptosis after exposure to cigarette smoke extract or ceramide.
conclusionsThese data support a role for epithelial Nrp1 in the maintenance of normal alveolar structure and suggest that dysregulation of Nrp1 expression may promote epithelial cell death in response to CS exposure, thereby enhancing emphysema development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.