ArticleAmerican journal of respiratory and critical care medicine2009
Effects of the menstrual cycle on lung function variables in women with asthma.
Article in American journal of respiratory and critical care medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- Sex differences in asthma symptom profiles and control in the American Lung Association Asthma Clinical Research Centers.Respiratory medicine · 2013Pooled it
- Sex, hormones, and lung health.Physiological reviews · 2026Review
- Sex Differences in Oxidative Stress Concerning Allergic Diseases.Biomolecules · 2025Review
- The Relationship Between Contraceptive Use and Respiratory Function in Women: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Life Course of Asthma.Advances in experimental medicine and biology · 2023Article
- A population-based cohort study on the risk of obstructive lung disease after bilateral oophorectomy.NPJ primary care respiratory medicine · 2022Article
- Menstrual Cycle-related Respiratory Symptom Variability in Patients with Lymphangioleiomyomatosis.Annals of the American Thoracic Society · 2022Article
- Sex, gender and the pulmonary physiology of exercise.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Sex and gender in asthma.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- A Prospective Study of the Effects of Sex Hormones on Lung Function and Inflammation in Women with Cystic Fibrosis.Annals of the American Thoracic Society · 2021Article
- Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma.Clinical and experimental pediatrics · 2021Article
- Insights from the Menstrual Cycle in Pulmonary Arterial Hypertension.Annals of the American Thoracic Society · 2021Observational
- Sex Hormones and Lung Inflammation.Advances in experimental medicine and biology · 2021Article
- Role of Sex Hormones at Different Physiobiological Conditions and Therapeutic Potential in MBD2 Mediated Severe Asthma.Oxidative medicine and cellular longevity · 2021Review
- Biological sex influences susceptibility to Acinetobacter baumannii pneumonia in mice.JCI insight · 2020Article
- Perimenstrual Asthma in Aspirin-Exacerbated Respiratory Disease.The journal of allergy and clinical immunology. In practice · 2020Article
- Novel Insights on Sex-Related Differences in Asthma.Current allergy and asthma reports · 2019Review
- Modulation of the lung inflammatory response to ozone by the estrous cycle.Physiological reports · 2019Article
- Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation.Biology of sex differences · 2018Article
- Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma.BMC pulmonary medicine · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleAngiogenesis is a defining pathologic feature of airway remodeling and contributes to asthma severity. Women experience changes in asthma control over the menstrual cycle, a time when vessels routinely form and regress under the control of angiogenic factors. One vital function modulated over the menstrual cycle in healthy women is gas transfer, and this has been related to angiogenesis and cyclic expansion of the pulmonary vascular bed.
objectivesWe hypothesized that changes in gas transfer and the pulmonary vascular bed occur in women with asthma over the menstrual cycle and are associated with worsening airflow obstruction.
methodsTwenty-three women, 13 with asthma and 10 healthy control subjects, were evaluated over the menstrual cycle with weekly measures of spirometry, gas transfer, nitric oxide, hemoglobin, factors affecting hemoglobin binding affinity, and proangiogenic factors. MEASUREMENTS AND MAIN
resultsAirflow and lung diffusing capacity varied over the menstrual cycle with peak levels during menses that subsequently declined to nadir in early luteal phase. In contrast to healthy women, changes in lung diffusing capacity (DL(CO)) were associated with changes in membrane diffusing capacity and DL(CO) was not related to proangiogenic factors. DL(CO) did not differ between the two groups, although methemoglobin and carboxyhemoglobin were higher in women with asthma than in healthy women.
conclusionsWomen with asthma experience cyclic changes in airflow as well as gas transfer and membrane diffusing capacity supportive of a hormonal effect on lung function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.