ArticleThe Journal of biological chemistry2009
Novel eicosapentaenoic acid-derived F3-isoprostanes as biomarkers of lipid peroxidation.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01183520 (Effect of High Omega-3 Fish Intake on Lipid Peroxidation), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of High Omega-3 Fish Intake on Lipid Peroxidation
Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Effect of omega-three polyunsaturated fatty acids on inflammation, oxidative stress, and recurrence of atrial fibrillation.The American journal of cardiology · 2015Trial
- Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers.Molecular nutrition & food research · 2014Trial
- Marine Phytoplankton Bioactive Lipids and Their Perspectives in Clinical Inflammation.Marine drugs · 2025Review
- Bioactive Oxylipins Profile in Marine Microalgae.Marine drugs · 2023Article
- Narrative Review ofNutrients · 2021Review
- Isoprostanoid Profiling of Marine Microalgae.Biomolecules · 2020Article
- Comprehensive profiling of prostaglandins in human ovarian follicular fluid using mass spectrometry.Prostaglandins & other lipid mediators · 2018Article
- Plasma F2-isoprostane class VI isomers at 12-18 weeks of pregnancy are associated with later occurrence of preeclampsia.Free radical biology & medicine · 2015Article
- The isoprostanes--25 years later.Biochimica et biophysica acta · 2015Review
- Role of the non-enzymatic metabolite of eicosapentaenoic acid, 5-epi-5-F3t-isoprostane in the regulation of [ (3)H]D-aspartate release in isolated bovine retina.Neurochemical research · 2014Article
- F3-Isoprostanes as a Measure of in vivo Oxidative Damage in Caenorhabditis elegans.Current protocols in toxicology · 2014Article
- Lipidomics of oxidized polyunsaturated fatty acids.Free radical biology & medicine · 2013Article
- Fatty acid-regulated transcription factors in the liver.Annual review of nutrition · 2013Review
- Omega-3 fatty acid supplementation and cardiovascular disease.Journal of lipid research · 2012Review
- Menhaden oil decreases high-fat diet-induced markers of hepatic damage, steatosis, inflammation, and fibrosis in obese Ldlr-/- mice.The Journal of nutrition · 2012Article
- Accurate quantification of lipid species by electrospray ionization mass spectrometry - Meet a key challenge in lipidomics.Metabolites · 2011Article
- Isoprostanes and asthma.Biochimica et biophysica acta · 2011Review
- Baking reduces prostaglandin, resolvin, and hydroxy-fatty acid content of farm-raised Atlantic salmon (Salmo salar).Journal of agricultural and food chemistry · 2011Article
- Isoprostane generation and function.Chemical reviews · 2011Review
- Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation.European heart journal · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Isoprostanes (iPs) are prostaglandin (PG) isomers generated by free radical-catalyzed peroxidation of polyunsaturated fatty acids (PUFAs). Urinary F(2)-iPs, PGF(2alpha) isomers derived from arachidonic acid (AA) are used as indices of lipid peroxidation in vivo. We now report the characterization of two major F(3)-iPs, 5-epi-8,12-iso-iPF(3alpha)-VI and 8,12-iso-iPF(3alpha)-VI, derived from the omega-3 fatty acid, eicosapentaenoic acid (EPA). Although the potential therapeutic benefits of EPA receive much attention, a shift toward a diet rich in omega-3 PUFAs may also predispose to enhanced lipid peroxidation. Urinary 5-epi-8,12-iso-iPF(3alpha)-VI and 8,12-iso-iPF(3alpha)-VI are highly correlated and unaltered by cyclooxygenase inhibition in humans. Fish oil dose-dependently elevates urinary F(3)-iPs in mice and a shift in dietary omega-3/omega-6 PUFAs is reflected by an increasing slope [m] of the line relating urinary 8, 12-iso-iPF(3alpha)-VI and 8,12-iso-iPF(2alpha)-VI. Administration of bacterial lipopolysaccharide evokes a reversible increase in both urinary 8,12-iso-iPF(3alpha)-VI and 8,12-iso-iPF(2alpha)-VI in humans on an ad lib diet. However, while excretion of the iPs is highly correlated (R(2) median = 0.8), [m] varies by an order of magnitude, reflecting marked inter-individual variability in the relative peroxidation of omega-3 versus omega-6 substrates. Clustered analysis of F(2)- and F(3)-iPs refines assessment of the oxidant stress response to an inflammatory stimulus in vivo by integrating variability in dietary intake of omega-3/omega-6 PUFAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.