ArticleCarcinogenesis2009
Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice.
Article in Carcinogenesis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Growth characteristics of HCT116 xenografts lacking asparagine synthetase vary according to sex.Human genomics · 2024Article
- Review
- Article
- Colitis-induced colorectal cancer and intestinal epithelial estrogen receptor beta impact gut microbiota diversity.International journal of cancer · 2019Article
- Significance of intratissue estrogen concentration coupled with estrogen receptors levels in colorectal cancer prognosis.Oncotarget · 2017Article
- Epithelial turnover in duodenal familial adenomatous polyposis: A possible role for estrogen receptors?World journal of gastroenterology · 2016Article
- A Versatile Strategy for Isolating a Highly Enriched Population of Intestinal Stem Cells.Stem cell reports · 2016Article
- Estrogen receptor beta as target for colorectal cancer prevention.Cancer letters · 2016Review
- The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice.Diabetologia · 2016Article
- Repeat polymorphisms in ESR2 and AR and colorectal cancer risk and prognosis: results from a German population-based case-control study.BMC cancer · 2014Article
- Estrogen receptor α or β loss in the colon of Min/+ mice promotes crypt expansion and impairs TGFβ and HNF3β signaling.Carcinogenesis · 2014Article
- Sex-dependent differences in intestinal tumorigenesis induced in Apc1638N/+ mice by exposure to γ rays.International journal of radiation oncology, biology, physics · 2013Article
- Estrogen receptors and human disease: an update.Archives of toxicology · 2012Review
- Mutation and association analyses of the candidate genes ESR1, ESR2, MAX, PCNA, and KAT2A in patients with unexplained MSH2-deficient tumors.Familial cancer · 2012Article
- Article
- Cyclin D1 expression in colorectal cancer is a favorable prognostic factor in men but not in women in a prospective, population-based cohort study.Biology of sex differences · 2011Article
- Immunohistochemical expression of estrogen and progesterone receptors in human colorectal adenoma and carcinoma using specified automated cellular image analysis system: a clinicopathological study.Oman medical journal · 2011Article
- A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Stromal deletion of the APC tumor suppressor in mice triggers development of endometrial cancer.Cancer research · 2011Article
- Enhanced induction of mucin-depleted foci in estrogen receptor {beta} knockout mice.Cancer prevention research (Philadelphia, Pa.) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 8 institutions in 3 countries.
Funding
Abstract
Estrogen receptors (ERs) [ERalpha (Esr1) and ERbeta (Esr2)] are expressed in the human colon, but during the multistep process of colorectal carcinogenesis, expression of both ERalpha and ERbeta is lost, suggesting that loss of ER function might promote colorectal carcinogenesis. Through crosses between an ERalpha knockout and Apc(Min) mouse strains, we demonstrate that ERalpha deficiency is associated with a significant increase in intestinal tumor multiplicity, size and burden in Apc(Min/+) mice. Within the normal intestinal epithelium of Apc(Min/+) mice, ERalpha deficiency is associated with an accumulation of nuclear beta-catenin, an indicator of activation of the Wnt-beta-catenin-signaling pathway, which is known to play a critical role in intestinal cancers. Consistent with the hypothesis that ERalpha deficiency is associated with activation of Wnt-beta-catenin signaling, ERalpha deficiency in the intestinal epithelium of Apc(Min/+) mice also correlated with increased expression of Wnt-beta-catenin target genes. Through crosses between an ERbeta knockout and Apc(Min) mouse strains, we observed some evidence that ERbeta deficiency is associated with an increased incidence of colon tumors in Apc(Min/+) mice. This effect of ERbeta deficiency does not involve modulation of Wnt-beta-catenin signaling. Our studies suggest that ERalpha and ERbeta signaling modulate colorectal carcinogenesis, and ERalpha does so, at least in part, by regulating the activity of the Wnt-beta-catenin pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.