ArticleEndocrinology2009
Paracrine signals from the mouse conceptus are not required for the normal progression of decidualization.
Article in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Decidualization-empowered ECM hydrogel integrating sustained Tβ4 release drives endometrial regeneration in intrauterine adhesions.Nature communications · 2026Article
- Murine implantation chamber formation precedes natural and artificial decidualization.bioRxiv : the preprint server for biology · 2025Article
- Uterine stromal but not epithelial PTGS2 is critical for murine pregnancy success.Reproduction (Cambridge, England) · 2025Article
- Effects of blastocyst elongation and implantation chamber formation on the alignment of the embryonic axis and uterine axis in mice.Frontiers in cell and developmental biology · 2024Article
- Vascular changes in the cycling and early pregnant uterus.JCI insight · 2023Review
- Transforming growth factor beta signaling and decidual integrity in mice†.Biology of reproduction · 2020Article
- Effects of Intrauterine Air Bubbles on Embryonic Development in Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Cutting Edge: Local Proliferation of Uterine Tissue-Resident NK Cells during Decidualization in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming.Matrix biology : journal of the International Society for Matrix Biology · 2017Article
- The decidua-the maternal bed embracing the embryo-maintains the pregnancy.Seminars in immunopathology · 2016Review
- Physiological and molecular determinants of embryo implantation.Molecular aspects of medicine · 2013Review
- Endometrial receptivity defects and impaired implantation in diabetic NOD mice.Biology of reproduction · 2012Article
- Angiopoietin-like gene expression in the mouse uterus during implantation and in response to steroids.Cell and tissue research · 2012Article
- Analysis of uterine gene expression in interleukin-15 knockout mice reveals uterine natural killer cells do not play a major role in decidualization and associated angiogenesis.Reproduction (Cambridge, England) · 2012Article
- Endometrial decidualization does not trigger the blood pressure decline of normal early pregnancy in mice.Biology of reproduction · 2012Article
- Evidence for a conserved function of heart and neural crest derivatives expressed transcript 2 in mouse and human decidualization.Reproduction (Cambridge, England) · 2011Article
- Tumor necrosis factor receptor subfamily 9 (Tnfrsf9) gene is expressed in distinct cell populations in mouse uterus and conceptus during implantation period of pregnancy.Cell and tissue research · 2011Article
- Microarray assessment of the influence of the conceptus on gene expression in the mouse uterus during decidualization.Reproduction (Cambridge, England) · 2011Article
- Natural killer cell-triggered vascular transformation: maternal care before birth?Cellular & molecular immunology · 2011Review
- Assessment of permeability barriers to macromolecules in the rodent endometrium at the onset of implantation.Methods in molecular biology (Clifton, N.J.) · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The purpose of this study was to determine whether the conceptus directs the formation of a tight- and adherens-dependent permeability barrier formed by the primary decidual zone and normal progression of decidual cell differentiation during embryo implantation. Four artificial models of decidualization were used, some apparently more physiological than others. The results show that both the formation of the permeability barrier and decidual cell differentiation of three of the artificial models were quite different from that of pregnant uteri. One artificial model of decidualization, namely pseudopregnant animals receiving concanavalin A-coated Sepharose bead transfers on d 2.5 of pseudopregnancy, better recapitulated the decidual changes that occur in the pregnant uterus undergoing decidualization. This included the formation of a primary decidual zone-like permeability barrier and decidual growth. This model also exhibited similar temporal changes of the expression of genes involved in decidualization that are markers of decidual cell differentiation. Overall, the results of this study indicate that some models of inducing decidualization artificially produce responses that are more similar to those occurring in the pregnant uterus, whereas others are quite different. More importantly, the results suggest that concanavalin A-coated Sepharose beads can provide an equivalent stimulus as the trophectoderm to cause the formation of the primary decidual zone permeability barrier.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.