ArticleJournal of the American Society of Nephrology : JASN2009
Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis.
Article in Journal of the American Society of Nephrology : JASN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Genome-wide association study of kidney function decline in individuals of European descent.Kidney international · 2015Pooled it
- Identification of putative kidney-derived proteins in plasma using nanoparticle enrichment.Molecular omics · 2026Article
- Chromogranin A: An Endocrine Factor of Pregnancy.International journal of molecular sciences · 2023Review
- Serum chromogranin A correlated with albuminuria in diabetic patients and is associated with early diabetic nephropathy.BMC nephrology · 2022Article
- Plasma Catestatin Levels and Advanced Glycation End Products in Patients on Hemodialysis.Biomolecules · 2021Article
- Chromogranin A pathway: from pathogenic molecule to renal disease.Journal of hypertension · 2020Article
- Role of TLR4 signaling in the nephrotoxicity of heme and heme proteins.American journal of physiology. Renal physiology · 2018Article
- Molecular Mechanism for Hypertensive Renal Disease: Differential Regulation of Chromogranin A Expression at 3'-Untranslated Region Polymorphism C+87T by MicroRNA-107.Journal of the American Society of Nephrology : JASN · 2015Article
- Adrenergic genetic mechanisms in hypertension and hypertensive kidney disease.Electrolyte & blood pressure : E & BP · 2013Article
- Catecholamine storage vesicles: role of core protein genetic polymorphisms in hypertension.Current hypertension reports · 2011Article
- Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease.Cellular and molecular neurobiology · 2010Article
- Essential hypertension and risk of nephropathy: a reappraisal.Current opinion in nephrology and hypertension · 2010Review
- Endothelin, hypertension and chronic kidney disease: new insights.Current opinion in nephrology and hypertension · 2010Review
- Genetic basis of nondiabetic end-stage renal disease.Seminars in nephrology · 2010Article
- Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis.American journal of nephrology · 2010Article
- Susceptibility genes in common complex kidney disease.Current opinion in nephrology and hypertension · 2010Review
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15 authors at 1 institution in 1 country.
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Abstract
Chromogranin A (CHGA), a protein released from secretory granules of chromaffin cells and sympathetic nerves, triggers endothelin-1 release from endothelial cells. CHGA polymorphisms associate with an increased risk for ESRD, but whether altered CHGA-endothelium interactions may explain this association is unknown. Here, CHGA led to the release of endothelin-1 and Weibel-Palade body exocytosis in cultured human umbilical vein endothelial cells. In addition, CHGA triggered secretion of endothelin-1 from glomerular endothelial cells and TGF-beta1 from mesangial cells cocultured with glomerular endothelial cells. In humans, plasma CHGA correlated positively with endothelin-1 and negatively with GFR. GFR was highly heritable in twin pairs, and common promoter haplotypes of CHGA predicted GFR. In patients with progressive hypertensive renal disease, a CHGA haplotype predicted rate of GFR decline. In conclusion, these data suggest that CHGA acts through the glomerular endothelium to regulate renal function.
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