ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2009
Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Phosphodiesterase V inhibition reduces airway responsiveness, but does not improve the beneficial effect of deep inspiration.Respiration; international review of thoracic diseases · 2013Trial
- Endoscopic Pseudo-dilation of Esophagogastric Junction During Peroral Endoscopic Myotomy: (With Video).DEN open · 2027Article
- Esophageal peristalsis in health and disease: mechanistic insights.Physiological reviews · 2026Review
- Pathophysiology of Gastroesophageal Reflux Disease.Digestion · 2026Review
- Effects of Cholecystokinin on Esophageal Motor Response to Distension in Asymptomatic Volunteers.Journal of neurogastroenterology and motility · 2024Article
- Pathophysiology of gastro-oesophageal reflux disease: implications for diagnosis and management.Nature reviews. Gastroenterology & hepatology · 2024Review
- Effects of Codeine on Esophageal Peristalsis in Patients With Ineffective Esophageal Motility: Studies Using High-resolution Manometry.Journal of neurogastroenterology and motility · 2024Article
- The contribution of lysophosphatidic acid receptors in the response of human lower esophageal sphincter under the electrical field stimulation.BMC gastroenterology · 2023Article
- LEtS set the tone.The Journal of physiology · 2022Article
- Neural signalling of gut mechanosensation in ingestive and digestive processes.Nature reviews. Neuroscience · 2022Review
- Three-Dimensional Pressure Profile of the Lower Esophageal Sphincter and Crural Diaphragm in Patients with Achalasia Esophagus.Gastroenterology · 2020Observational
- Neuronal Control of Esophageal Peristalsis and Its Role in Esophageal Disease.Current gastroenterology reports · 2019Review
- Ineffective esophageal motility: Concepts, future directions, and conclusions from the Stanford 2018 symposium.Neurogastroenterology and motility · 2019Review
- Cholecystokinin induces esophageal longitudinal muscle contraction and transient lower esophageal sphincter relaxation in healthy humans.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Regulation and dysregulation of esophageal peristalsis by the integrated function of circular and longitudinal muscle layers in health and disease.American journal of physiology. Gastrointestinal and liver physiology · 2016Review
- The Physiology of Eructation.Dysphagia · 2016Review
- Role of BKBioMed research international · 2016Article
- Circular and longitudinal muscles shortening indicates sliding patterns during peristalsis and transient lower esophageal sphincter relaxation.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Esophageal function testing: beyond manometry and impedance.Gastrointestinal endoscopy clinics of North America · 2014Review
- The spectrum of achalasia: lessons from studies of pathophysiology and high-resolution manometry.Gastroenterology · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We recently found that an orally directed stretch of the esophagus activates a neurally mediated relaxation of the lower esophageal sphincter (LES). Goals of our study were to characterize the neural mechanisms responsible for axial and transverse stretch-activated responses in the LES. LES pressure was monitored in anesthetized and artificially ventilated mice. Sutures were placed in the esophagus to exert graded stretch in the longitudinal and transverse directions. Effects of bilateral vagotomy and pharmacological agents on the stretch-activated LES responses were investigated. The relationship between vagally stimulated axial stretch and LES relaxation was also studied. Stretch in the longitudinal and transverse directions caused a dose-dependent LES relaxation and contraction, respectively, that were not affected by bilateral vagotomy and sympathectomy but were blocked by tetrodotoxin. In bilateral vagotomized animals, hexamethonium, atropine, pyridoxalphosphate-6-azophenyl-2',4' disulfonic acid (PPADS), and ondansetron did not block the stretch-activated LES relaxation and contraction. Axial stretch-activated LES relaxation was blocked by nitric oxide inhibitor and transverse stretch-activated LES contraction was blocked by a combination of atropine and substance P antagonist. Electrical stimulation of the vagus nerve induced LES relaxation and axial stretch on the LES, both of which were blocked by rocuronium. Axial and transverse stretch-activated LES relaxation and contraction were present in the W/W(v) mice that lack interstitial cells of Cajal (ICC). Stretch-activated LES relaxation and contraction are mediated through mechanosensitive neurons located in the myenteric plexus, which involves neither synaptic transmission nor ICC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.