ArticleCritical care (London, England)2009
Dose of dialysis in the intensive care unit: is the venom in the dose or in the clinical experience?
Article in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Intensive care unit continuous kidney replacement therapy: time to change dosage recommendations?International urology and nephrology · 2025Review
- The concept of justifiable healthcare and how big data can help us to achieve it.BMC medical informatics and decision making · 2021Review
- Clinical review: Optimal dose of continuous renal replacement therapy in acute kidney injury.Critical care (London, England) · 2011Review
- Continuous Renal Replacement Therapy Dosing in the Severely Underweight: A Case Report.Kidney medicineArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many studies on the most 'adequate' dose of renal replacement therapy (RRT) in critically ill patients with acute kidney injury have obtained contradictory results. The previous issue of Critical Care reports a multi-centre study showing that a higher than conventional dose of RRT, whether continuous RRT or intermittent RRT, is not associated with better survival of these patients. This commentary highlights some of the problems associated with the interpretation of this and previously published studies. These problems include the use of targets of Kt/V urea or the ultrafiltration rate in millilitres per kilogram body weight, the latter quite difficult to estimate in these patients, the divergent co-morbidities of the patients, and the local experience of intensivists or nephrologists with either continuous RRT or intermittent RRT. The last factor could explain why some single centre studies did find an impact of dialysis dose on the survival of these patients whereas multi-centre studies did not.
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Registered trials
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