ArticleCritical care (London, England)2009
Early down-regulation of the pro-inflammatory potential of monocytes is correlated to organ dysfunction in patients after severe multiple injury: a cohort study.
Article in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Immune capacity determines outcome following surgery or trauma: a systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Pooled it
- The immunomodulatory effect of sugammadex in vitro and after total hip arthroplasty : A randomised controlled pilot and retrospective cohort study.European journal of anaesthesiology · 2025Trial
- Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial.Critical care (London, England) · 2010Trial
- Beyond injury severity: monocyte-associated small extracellular vesicles distinguish respiratory-support trajectories following thoracic trauma.BMC pulmonary medicine · 2026Article
- A comprehensive overview of fixed-volume hemorrhage effects in New Zealand White rabbit models.Open veterinary journal · 2025Article
- The effect of general versus spinal anesthesia on perioperative innate immune function in patients undergoing total hip arthroplasty.BMC anesthesiology · 2025Article
- During Sepsis and COVID-19, the Pro-Inflammatory and Anti-Inflammatory Responses Are Concomitant.Clinical reviews in allergy & immunology · 2023Review
- Immune changes induced by periampullary adenocarcinoma are reversed after tumor resection and modulate the postoperative survival.Discover oncology · 2023Article
- Reduced phagocytosis, ROS production and enhanced apoptosis of leukocytes upon alcohol drinking in healthy volunteers.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022Article
- Review
- Unveiling the Pathogenesis of Adenomyosis through Animal Models.Journal of clinical medicine · 2022Review
- Article
- Severe Traumatic Injury Induces Phenotypic and Functional Changes of Neutrophils and Monocytes.Journal of clinical medicine · 2021Article
- Neuroendocrine Modulation of the Immune Response after Trauma and Sepsis: Does It Influence Outcome?Journal of clinical medicine · 2020Review
- Article
- Effectiveness of fecal microbiota transplantation for severe diarrhea after drug-induced hypersensitivity syndrome.Medicine · 2019Article
- The impact of the systemic inflammatory response on hepatic bacterial elimination in experimental abdominal sepsis.Intensive care medicine experimental · 2019Article
- Soluble tumour necrosis factor receptor I is a promising early indicator of complicated clinical outcome in patients following severe trauma.Central-European journal of immunology · 2019Article
- CD14+ Monocytic Cytokines: Impact on Outcome in Severely Injured Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2018Article
- Reduced NLRP3 Gene Expression Limits the IL-1Mediators of inflammation · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSevere tissue trauma results in a general inflammatory immune response (SIRS) representing an overall inflammatory reaction of the immune system. However, there is little known about the functional alterations of monocytes in the early posttraumatic phase, characterized by the battle of the individual with the initial trauma.
methodsThirteen patients with severe multiple injury; injury severity score (ISS) >16 points (17 to 57) were included. The cytokine synthesis profiles of monocytes were characterized on admission, and followed up 6, 12, 24, 48, and 72 hours after severe multiple injury using flow cytometry. Whole blood was challenged with lipopolysaccharide (LPS) and subsequently analyzed for intracellular monocyte-related TNF-alpha, IL-1beta, IL-6, and IL-8. The degree of organ dysfunction was assessed using the multiple organ dysfunction syndrome (MODS)-score of Marshall on admission, 24 hours and 72 hours after injury.
resultsOur data clearly show that the capacity of circulating monocytes to produce these mediators de novo was significantly diminished very early reaching a nadir 24 hours after severe injury followed by a rapid and nearly complete recovery another 48 hours later compared with admission and controls, respectively. In contrast to the initial injury severity, there was a significant correlation detectable between the clinical signs of multiple organ dysfunction and the ex vivo cytokine response.
conclusionsAs our data derived from very narrow intervals of measurements, they might contribute to a more detailed understanding of the early immune alterations recognized after severe trauma. It can be concluded that indeed as previously postulated an immediate hyperactivation of circulating monocytes is rapidly followed by a substantial paralysis of cell function. Moreover, our findings clearly demonstrate that the restricted capacity of monocytes to produce proinflammatory cytokines after severe injury is not only an in vitro phenomenon but also undistinguishable associated with the onset of organ dysfunction in the clinical scenario.
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