ArticleJournal of neurochemistry2009
Antiapoptotic effects of vasopressin in the neuronal cell line H32 involve protein kinase Calpha and beta.
Article in Journal of neurochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Claudin 14/15 play important roles in early wallerian degeneration after rat sciatic nerve injury.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2021Article
- Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size.International journal of molecular sciences · 2021Article
- Terlipressin protects intestinal epithelial cells against oxygen-glucose deprivation/re-oxygenation injury via the phosphatidylinositol 3-kinase pathway.Experimental and therapeutic medicine · 2017Article
- Signaling through hepatocyte vasopressin receptor 1 protects mouse liver from ischemia-reperfusion injury.Oncotarget · 2016Article
- PreImplantation Factor bolsters neuroprotection via modulating Protein Kinase A and Protein Kinase C signaling.Cell death and differentiation · 2015Article
- Vasopressin inhibits apoptosis in renal collecting duct cells.American journal of physiology. Renal physiology · 2013Article
- Dynamics of the G protein-coupled vasopressin V2 receptor signaling network revealed by quantitative phosphoproteomics.Molecular & cellular proteomics : MCP · 2012Article
- Article
- Vasopressin protects hippocampal neurones in culture against nutrient deprivation or glutamate-induced apoptosis.Journal of neuroendocrinology · 2010Article
- Binge-pattern alcohol exposure during puberty induces sexually dimorphic changes in genes regulating the HPA axis.American journal of physiology. Endocrinology and metabolism · 2010Article
- Interaction of stress, corticotropin-releasing factor, arginine vasopressin and behaviour.Current topics in behavioral neurosciencesArticle
- HPA axis responsiveness to stress: implications for healthy aging.Experimental gerontologyReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Activation of V1 vasopressin (VP) receptors prevents serum deprivation-induced apoptosis in neuronal H32 cells, partially through mitogen-activated protein kinase (MAPK) mediated Bad phosphorylation. In this study, we investigated the role of protein kinases C (PKC) and B (PKB) mediating VP-induced antiapoptosis in H32 cells. Serum deprivation increased PKCdelta but not PKCalpha or PKCbeta activity, while VP increased PKCalpha and PKCbeta without affecting PKCdelta activity. Inhibition of PKCdelta prevented caspase 3 activation, indicating that PKCdelta mediates the pro-apoptotic actions of serum deprivation. Simultaneous inhibition of PKCalpha and beta and MAPK abolished VP-induced Bad phosphorylation, but it only partially prevented caspase 3 inhibition. Complete abolition of the protective effect of VP on serum deprivation-induced caspase 3 activity required additional blockade of phosphoinositide 3 kinase (PI3K)/protein kinase B. The data demonstrate that VP exerts antiapoptosis through multiple pathways; while PKCalpha and beta together with extracellular signal-regulated kinases/MAPK activation mediates Bad phosphorylation (inactivation), the full protective action of VP requires additional activation of PKB (PI3K/protein kinase B) pathway.
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Registered trials
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