ArticleThe European journal of neuroscience2009
The maintenance of specific aspects of neuronal function and behavior is dependent on programmed cell death of adult-generated neurons in the dentate gyrus.
Article in The European journal of neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Contributions of adult neurogenesis to dentate gyrus network activity and computations.Behavioural brain research · 2019Review
- Multifaceted circuit functions of adult-born neurons.F1000Research · 2019Review
- Article
- Targeting Adult Neurogenesis for Poststroke Therapy.Stem cells international · 2017Review
- Differential Activation of Mitogen-Activated Protein Kinases, ERK 1/2, p38(MAPK) and JNK p54/p46 During Postnatal Development of Rat Hippocampus.Neurochemical research · 2016Article
- Control of adult neurogenesis by programmed cell death in the mammalian brain.Molecular brain · 2016Review
- Bacterial Peptidoglycan Traverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal BehaviorCell host & microbe · 2016Article
- Hyperactivity and depression-like traits in Bax KO mice.Brain research · 2015Article
- Control of Cell Survival in Adult Mammalian Neurogenesis.Cold Spring Harbor perspectives in biology · 2015Review
- MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells.Scientific reports · 2015Article
- Effect of dentate gyrus disruption on remembering what happened where.Frontiers in behavioral neuroscience · 2015Article
- P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage.Cell · 2014Article
- Using the neurofibromatosis tumor predisposition syndromes to understand normal nervous system development.Scientifica · 2014Review
- Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus.Nature neuroscience · 2013Article
- Cell biology in neuroscience: Death of developing neurons: new insights and implications for connectivity.The Journal of cell biology · 2013Review
- Postnatal Development of Subcallosal Zone Following Suppression of Programmed Cell Death in Bax-deficient Mice.Development & reproduction · 2013Article
- Aging- and injury-related differential apoptotic response in the dentate gyrus of the hippocampus in rats following brain trauma.Frontiers in aging neuroscience · 2013Article
- The influence of ectopic migration of granule cells into the hilus on dentate gyrus-CA3 function.PloS one · 2013Article
- Genetic control of adult neurogenesis: interplay of differentiation, proliferation and survival modulates new neurons function, and memory circuits.Frontiers in cellular neuroscience · 2013Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
A considerable number of new neurons are generated daily in the dentate gyrus (DG) of the adult hippocampus, but only a subset of these survive, as many adult-generated neurons undergo programmed cell death (PCD). However, the significance of PCD in the adult brain for the functionality of DG circuits is not known. Here, we examined the electrophysiological and behavioral characteristics of Bax-knockout (Bax-KO) mice in which PCD of post-mitotic neurons is prevented. The continuous increase in DG cell numbers in Bax-KO mice resulted in the readjustment of afferent and efferent synaptic connections, represented by age-dependent reductions in the dendritic arborization of DG neurons and in the synaptic contact ratio of mossy fibers with CA3 dendritic spines. These neuroanatomical changes were associated with reductions in synaptic transmission and reduced performance in a contextual fear memory task in 6-month-old Bax-KO mice. These results suggest that the elimination of excess DG neurons via Bax-dependent PCD in the adult brain is required for the normal organization and function of the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.