ReviewCurrent pharmaceutical design2009
Lactoferrin as a natural immune modulator.
Review in Current pharmaceutical design, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04335058 (Lactoferrin With Iron Versus Iron Alone in Treatment of Anemia In Chronic Liver Disease), which is not on this map. Cited by 194 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lactoferrin With Iron Versus Iron Alone in Treatment of Anemia In Chronic Liver Disease
Who cites it
194 citing papers in PubMed, 3 syntheses or guidelines pooled it, 442 citations in OpenAlex.
- Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- The effects of orally administered lactoferrin in the prevention and management of viral infections: A systematic review.Reviews in medical virology · 2022Pooled it
- Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis.BMC oral health · 2020Pooled it
- Effects of Bovine Lactoferrin on Vaginal Microbiota in Healthy Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Trial.Nutrients · 2026Trial
- Effect of A1 protein-free formula versus conventional formula on acute respiratory infections and diarrhea in toddlers: A Randomized Controlled Trial.Journal of pediatric gastroenterology and nutrition · 2025Trial
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- New insights into diagnostic values and mechanisms of ferroptosis associated with immune infiltration in diabetic kidney disease.Experimental and therapeutic medicine · 2026Article
- Camel Milk Extracellular Vesicles as Engineered Biogenic Particles: Thermosensitive Hydrogel Integration for Optimized Wound Delivery and Tissue Regeneration.Pharmaceutics · 2026Article
- Lactoferrin reduces febrile neutropenia in children receiving chemotherapy for hematologic malignancies: a randomized, placebo-controlled trial.Haematologica · 2026Article
- Effects of breed and colostrum replacer quantity on lymphocyte populations in the blood of Holstein and HolsteinJDS communications · 2026Article
- The Protective and Regenerative Potential of Lactoferrin in Hair and Skin Health.International journal of molecular sciences · 2026Review
- Immunomodulatory Role of Milk on Gut Microbiota: Implications for Enhancing Oral Vaccine Efficacy.Probiotics and antimicrobial proteins · 2026Review
- Optimizing Lactoferrin Isolation for Functional and Structural Integrity: A Molecular Insight.Molecules (Basel, Switzerland) · 2026Review
- Iron acquisition mechanisms of human skin-associated fungi.FEMS yeast research · 2026Review
- Lactoferrin-Conjugated Nanocarriers for Transformative Strategies in Cancer Management: New Insights on Breast Cancer Therapy.Current drug delivery · 2026Review
- Lactoferrin inhibits anoikis-resistance and metastasis of nasopharyngeal carcinoma cells via the AKT signaling pathway.International journal of clinical and experimental pathology · 2026Article
- ExploitingFrontiers in immunology · 2026Article
134 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Lactoferrin, an iron-binding glycoprotein, is a cell-secreted mediator that bridges innate and adaptive immune function in mammals. It is a pleiotropic molecule that directly assists in the influence of presenting cells for the development of T-helper cell polarization. The aim of this review is to provide an overview of research regarding the role of lactoferrin in maintaining immune homeostasis, in particular as a mediator of immune responses to infectious assault, trauma and injury. These findings are critically relevant in the development of both prophylactic and therapeutic interventions in humans. Understanding these particular effects of lactoferrin will provide a logical framework for determining its role in health and disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.