ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 68 citations in OpenAlex.
- The Interaction Between theInternational journal of molecular sciences · 2025Article
- Genome and gene evolution of seahorse species revealed by the chromosome-level genome of Hippocampus abdominalis.Molecular ecology resources · 2022Article
- Insights Gained From Zebrafish Models for the Ciliopathy Joubert Syndrome.Frontiers in genetics · 2022Review
- Role of Primary Cilia in Skeletal Disorders.Stem cells international · 2022Review
- Loss of zebrafish dzip1 results in inappropriate recruitment of periocular mesenchyme to the optic fissure and ocular coloboma.PloS one · 2022Article
- Ttc30a affects tubulin modifications in a model for ciliary chondrodysplasia with polycystic kidney disease.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Zebrafish Models for Human Skeletal Disorders.Frontiers in genetics · 2021Review
- Exome sequencing analysis identifies frequent oligogenic involvement andJournal of medical genetics · 2020Article
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- Article
- The Bardet-Biedl syndrome protein complex regulates cell migration and tissue repair through a Cullin-3/RhoA pathway.American journal of physiology. Cell physiology · 2019Article
- Intraflagellar transport proteins are involved in thrombocyte filopodia formation and secretion.Platelets · 2018Article
- Characterization of Endothelial Cilia Distribution During Cerebral-Vascular Development in Zebrafish ( Danio rerio).Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Review
- Developmental expression of the zebrafish Arf-like small GTPase paralogs arl13a and arl13b.Gene expression patterns : GEP · 2018Article
- Ift172 conditional knock-out mice exhibit rapid retinal degeneration and protein trafficking defects.Human molecular genetics · 2018Article
- Autosomal recessive IFT57 hypomorphic mutation cause ciliary transport defect in unclassified oral-facial-digital syndrome with short stature and brachymesophalangia.Clinical genetics · 2016Article
- Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish.Investigative ophthalmology & visual science · 2016Article
- Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin-binding IFT-B2 complex.The EMBO journal · 2016Article
- Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish.Development (Cambridge, England) · 2015Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Cilia formation requires intraflagellar transport (IFT) proteins. Recent studies indicate that mammalian Hedgehog (Hh) signaling requires cilia. It is unclear, however, if the requirement for cilia and IFT proteins in Hh signaling represents a general rule for all vertebrates. Here we examine zebrafish ift57, ift88, and ift172 mutants and morphants for defects in Hh signaling. Although ift57 and ift88 mutants and morphants contained residual maternal protein, the cilia were disrupted. In contrast to previous genetic studies in mouse, mutations in zebrafish IFT genes did not affect the expression of Hh target genes in the neural tube and forebrain and had no quantitative effect on Hh target gene expression. Zebrafish IFT mutants also exhibited no dramatic changes in the craniofacial skeleton, somite formation, or motor neuron patterning. Thus, our data indicate the requirement for cilia in the Hh signal transduction pathway may not represent a universal mechanism in vertebrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.