ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Transgenesis in Xenopus using the Sleeping Beauty transposon system.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The use of transgenics in the laboratory axolotl.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Review
- Expanding the genetic toolkit in Xenopus: Approaches and opportunities for human disease modeling.Developmental biology · 2017Review
- Budgett's frog (Lepidobatrachus laevis): A new amphibian embryo for developmental biology.Developmental biology · 2015Article
- Exogenous enzymes upgrade transgenesis and genetic engineering of farm animals.Cellular and molecular life sciences : CMLS · 2015Review
- Interrogating transcriptional regulatory sequences in Tol2-mediated Xenopus transgenics.PloS one · 2013Article
- Characterization of a novel Xenopus tropicalis cell line as a model for in vitro studies.Genesis (New York, N.Y. : 2000) · 2012Article
- Optimized transgenesis in Xenopus laevis/gilli isogenetic clones for immunological studies.Genesis (New York, N.Y. : 2000) · 2012Article
- Remobilization of Sleeping Beauty transposons in the germline of Xenopus tropicalis.Mobile DNA · 2011Article
- Pig transgenesis by Sleeping Beauty DNA transposition.Transgenic research · 2011Article
- Xenopus: An emerging model for studying congenital heart disease.Birth defects research. Part A, Clinical and molecular teratology · 2011Review
- Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish.PloS one · 2011Article
- Differential sensitivities of retroviruses to integrase strand transfer inhibitors.Journal of virology · 2011Article
- Transposon transgenesis in Xenopus.Methods (San Diego, Calif.) · 2010Review
- Remobilization of Tol2 transposons in Xenopus tropicalis.BMC developmental biology · 2010Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Transposon-based integration systems have been widely used for genetic manipulation of invertebrate and plant model systems. In the past decade, these powerful tools have begun to be used in vertebrates for transgenesis, insertional mutagenesis, and gene therapy applications. Sleeping Beauty (SB) is a member of Tc1/mariner class of transposases and is derived from an inactive form of the gene isolated from Atlantic salmon. SB has been used extensively in human cell lines and in whole animal vertebrate model systems such as the mouse, rat, and zebrafish. In this study, we describe the use of SB in the diploid frog Xenopus tropicalis to generate stable transgenic lines. SB transposon transgenes integrate into the X. tropicalis genome by a noncanonical process and are passed through the germline. We compare the activity of SB in this model organism with that of Tol2, a hAT (hobo, Ac1, TAM)-like transposon system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.