Evidence map›Paper›PMID 19517245›Full record

ArticleNeuroscience and behavioral physiology2009

The contribution of serotonin 1A receptors to kappa opioid immunosuppression.

M A Cheido, G V Idova

Abstract read
PubMed Publisher
In one paragraph

Article in Neuroscience and behavioral physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

M A CheidoState Research Institute of Physiology, Siberian Branch, Russian Academy of Medical Sciences, 4 Academician Timakov Street, 630117, Novosibirsk, Russia. margo@iph.ma.nsc.ru
G V Idova
Russian Academy of Sciences · RUSiberian Branch of the Russian Academy of Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of kappa opioid receptors (kappa-OR) with the selective agonist rimorphin (0.1 mg/kg) produced marked suppression of the immune response in CBA mice. This effect was not seen on administration of rimorphin on the background of a reduction in the activity of the serotoninergic (5-HTergic) system resulting from stimulation of presynaptic (8-OH-DPAT, 0.1 mg/kg) or blockade of postsynaptic (WAY-100635, 1.0 mg/kg) 5-HT1A receptors. These data led to the conclusion that 5-HTergic mechanisms involving preand postsynaptic 5-HT1A receptors have a role in kappa-opioid-mediated immunosuppression.

Indexed as

Immunosuppression Therapy8-Hydroxy-2-(di-n-propylamino)tetralinAnimalsDynorphinsEndorphinsMaleMiceMice, Inbred CBANeuroimmunomodulationPiperazinesPyridinesReceptor, Serotonin, 5-HT1AReceptors, Opioid, kappaReceptors, PresynapticSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor Antagonists8-Hydroxy-2-(di-n-propylamino)tetralinDynorphinsEndorphinsN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamidePiperazinesPyridinesReceptor, Serotonin, 5-HT1AReceptors, Opioid, kappaReceptors, PresynapticrimorphinSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor Antagonists

Identifiers

PMID19517245
OpenAlexW2051526076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.