ArticleCellular and molecular neurobiology2009
Neuroprotective and antioxidative effect of cactus polysaccharides in vivo and in vitro.
Article in Cellular and molecular neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Pooled it
- Using Plant-Derived Polysaccharides in the Management of Cognitive Disorders: Molecular and Clinical Perspectives.Nutrients · 2026Review
- Cladodes ofPlants (Basel, Switzerland) · 2024Article
- Tanshinone IIA Alleviates Traumatic Brain Injury by Reducing Ischemia‒Reperfusion via the miR-124-5p/FoxO1 Axis.Mediators of inflammation · 2024Article
- Review
- A Study on the Time-Effect and Dose-Effect Relationships of Polysaccharide fromFoods (Basel, Switzerland) · 2022Article
- Protective Effect ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Traditional Herbal Medicines Against CNS Disorders from Bangladesh.Natural products and bioprospecting · 2020Review
- Review
- Food-Derived Antioxidant Polysaccharides and Their Pharmacological Potential in Neurodegenerative Diseases.Nutrients · 2017Review
- Anvillea garcinii extract inhibits the oxidative burst of primary human neutrophils.BMC complementary and alternative medicine · 2016Article
- A Potential Alternative against Neurodegenerative Diseases: Phytodrugs.Oxidative medicine and cellular longevity · 2016Review
- Novel antiepileptic drug lacosamide exerts neuroprotective effects by decreasing glial activation in the hippocampus of a gerbil model of ischemic stroke.Experimental and therapeutic medicine · 2015Article
- Anti-tumor effect of cactus polysaccharides on lung squamous carcinoma cells (SK-MES-1).African journal of traditional, complementary, and alternative medicines : AJTCAM · 2014Article
- Protective effects of a novel synthetic α-lipoic acid-decursinol hybrid compound in experimentally induced transient cerebral ischemia.Cellular and molecular neurobiology · 2012Article
- Comparison of the structural characterization and biological activity of acidic polysaccharides from Cordyceps militaris cultured with different media.World journal of microbiology & biotechnology · 2012Article
- Phenolic alkaloids from Menispermum dauricum rhizome protect against brain ischemia injury via regulation of GLT-1, EAAC1 and ROS generation.Molecules (Basel, Switzerland) · 2012Article
- EGCG ameliorates the suppression of long-term potentiation induced by ischemia at the Schaffer collateral-CA1 synapse in the rat.Cellular and molecular neurobiology · 2012Article
- Lycium barbarum extracts protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke.PloS one · 2012Article
- Fasudil mesylate protects PC12 cells from oxidative stress injury via the Bax-mediated pathway.Cellular and molecular neurobiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cactus polysaccharides (CP), some of the active components in Opuntia dillenii Haw have been reported to display neuroprotective effects in rat brain slices. In the present study, we investigated the neuroprotective properties of CP and their potential mechanisms on brain ischemia-reperfusion injury in rats, and on oxidative stress-induced damage in PC12 cells. Male Sprague-Dawley rats with ischemia following middle cerebral artery occlusion and reperfusion were investigated. CP (200 mg/kg) significantly decreased the neurological deficit score, reduced infarct volume, decreased neuronal loss in cerebral cortex, and remarkably reduced the protein synthesis of inducible nitric oxide synthase which were induced by ischemia and reperfusion. Otherwise, the protective effect of CP was confirmed in in vitro study. CP protected PC12 cells against hydrogen peroxide (H(2)O(2)) insult. Pretreatment with CP prior to H(2)O(2) exposure significantly elevated cell viability, reduced H(2)O(2)-induced apoptosis, and decreased both intracellular and total accumulation of reactive oxygen species (ROS) production. Furthermore, CP also reversed the upregulation of Bax/Bcl-2 mRNA ratio, the downstream cascade following ROS. These results suggest that CP may be a candidate compound for the treatment of ischemia and oxidative stress-induced neurodegenerative disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.