ArticleCellular and molecular neurobiology2009
The neuroprotective effects of ginsenosides on calcineurin activity and tau phosphorylation in SY5Y cells.
Article in Cellular and molecular neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Neuroprotective Effects of Glucosamine in Huntington's Disease Through NLRP3 Inflammasome Inhibition.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Phytochemicals Targeting BDNF Signaling for Treating Neurological Disorders.Brain sciences · 2025Review
- The Antioxidative Effects of Picein and Its Neuroprotective Potential: A Review of the Literature.Molecules (Basel, Switzerland) · 2022Review
- Anti-neuroinflammatory of Chloroform Extract ofReports of biochemistry & molecular biology · 2022Article
- Role of ginseng in the neurovascular unit of neuroinflammatory diseases focused on the blood-brain barrier.Journal of ginseng research · 2021Article
- Neuroprotective Effect and Antioxidant Potency of Fermented Cultured Wild Ginseng Root Extracts ofMolecules (Basel, Switzerland) · 2021Article
- Panaxadiol saponins treatment caused the subtle variations in the global transcriptional state of Asiatic corn borer,Journal of ginseng research · 2020Article
- Protective Effects of Red Ginseng Oil against AβInternational journal of molecular sciences · 2017Article
- Antiaging effects of the mixture ofJournal of ginseng research · 2017Article
- A Role of Ginseng and Its Constituents in the Treatment of Central Nervous System Disorders.Evidence-based complementary and alternative medicine : eCAM · 2016Review
- Protective effects of ginseng on neurological disorders.Frontiers in aging neuroscience · 2015Review
- Shenfu injection attenuates neonatal hypoxic-ischemic brain damage in rat.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system.Journal of ginseng research · 2013Article
- Effects of Panax ginseng in Neurodegenerative Diseases.Journal of ginseng research · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcineurin (CN) is a Ca(2+)/calmodulin-dependent protein phosphatase expressed at high levels in brain. Many findings have shown that calcineurin plays an important role in tau hyperphosphorylation, which is one of the neuropathologic features in the brains of Alzheimer's disease (AD). Based on the molecular screening model using p-nitrophenyl phosphate (p-NPP) as a substrate for preliminary screening and (32)P-labeled 19-residue phosphopeptide as a specific substrate for final determination, we found that the total ginsenoside extracts from stems and leaves of Panax ginseng (GSL) could enhance the phosphatase activity of purified CN. In the human neuroblastoma cells SY5Y, inhibition of CN by cyclosporine A (CsA) could induce hyperphosphorylation of tau at multiple sites, accompanied with oxidative stress. Pretreatment of the cells with GSL prior to CsA exposure could alleviate CsA-induced CN inhibition and tau hyperphosphorylation to some degree. Further oxidative parameters demonstrated that GSL caused increased SOD activity and content of SH significantly. It is speculated that GSL weakens CsA-induced CN inhibition through the antioxidant mechanisms. Although our results indicate that GSL may have neuroprotective effects on some characteristic features of AD, the chemical compositions of GSL and their potential for affecting the disease mechanism need to be further studied.
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