SynthesisClinical orthopaedics and related research2009
Prophylaxis of heterotopic ossification of the hip: systematic review and meta-analysis.
Synthesis in Clinical orthopaedics and related research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Does computer-assisted surgery improve postoperative leg alignment and implant positioning following total knee arthroplasty? A meta-analysis of randomized controlled trials?Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Pooled it
- Does minimally invasive surgery improve short-term recovery in total knee arthroplasty?Clinical orthopaedics and related research · 2010Pooled it
- Anterior subcutaneous internal fixator (INFIX) versus plate fixation for pelvic anterior ring fracture.Scientific reports · 2019Trial
- No Added Benefit of Nonsteroidal Anti-Inflammatory Drug Prophylaxis Beyond 15 Days for Heterotopic Ossification After Hip Arthroscopy.Orthopaedic journal of sports medicine · 2026Article
- Reduction in utilization of radiation for heterotopic ossification prophylaxis following acetabular surgery during the COVID-19 pandemic.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- TGF-β signaling in heterotopic ossification: the pathogenesis and the target for its treatment.Journal of orthopaedic surgery and research · 2025Review
- Severe heterotopic ossification after total hip arthroplasty in male patients under 70 years of age: effectiveness of prophylactic protocol.Musculoskeletal surgery · 2025Article
- Heterotopic ossification (HO) prophylaxis in total hip arthroplasty (THA): A systematic review of level I and level II evidence since 2000.Bone reports · 2025Review
- Fibroblasts in heterotopic ossification: mechanisms and therapeutic targets.International journal of biological sciences · 2025Review
- Surgical Treatment of Post-Traumatic Radio-Ulnar Synostosis.Medicina (Kaunas, Lithuania) · 2024Review
- Heterotopic ossification following total hip arthroplasty. Which is the predominant risk factor: surgical approach or post-operative prophylaxis?International orthopaedics · 2024Article
- Clinical study of modified INFIX combined with sacroiliac joint screws for pelvic instable injuries.BMC surgery · 2023Article
- Heterotopic ossification in primary total hip arthroplasty: risk factor analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Article
- Low-dose prophylaxis protocol for heterotopic ossification after hip preservation surgery in a sport participants cohort.SICOT-J · 2023Article
- Patellar Tendon Reconstruction Using Autologous Hamstring Tendons for the Treatment of Extensive Patellar Tendon Ossification.Orthopaedic surgery · 2022Article
- Palovarotene Can Attenuate Heterotopic Ossification Induced by Tendon Stem Cells by Downregulating the Synergistic Effects of Smad and NF-Stem cells international · 2022Article
- Comparing Options for Heterotopic Ossification Prophylaxis following Elbow Trauma: A Systematic Review and Meta-Analysis.Journal of hand and microsurgery · 2021Article
- [Omitted prophylaxis of heterotopic ossification].Der Orthopade · 2020Article
- Radiation therapy for the prevention of heterotopic ossification: Efficacy and toxicity of single fraction radiotherapy.Orthopedic reviews · 2020Article
- Use of Acellular Dermal Matrix to Prevent Recurrence of Radioulnar Heterotopic Ossification.Plastic and reconstructive surgery. Global open · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterotopic ossification (HO) is a potentially severe, if infrequent, complication in hip surgery, and uncertainty exists regarding whether to use NSAIDs or radiation in its prevention. Thus, we systematically reviewed the literature in MedLine, EMBASE, CINAHL, and the Cochrane Controlled Trial Register and, after ruling out publication bias and data heterogeneity, performed a meta-analysis of randomized, controlled trials to assess effectiveness and complications of NSAIDs and radiation in the prevention of HO. We identified nine studies reporting on effectiveness and complications including a total of 1295 patients. The pooled risk ratio for the effectiveness in HO prevention was 0.96 (95% confidence interval, 0.88-1.06) and was independent of the type of surgery (THA or open reduction and internal fixation). There was no association with gender, age, length of followup, or year of publication. The risk ratio for associated complications was 0.79 (95% confidence interval, 0.45-1.41), and, again, was independent of the aforementioned factors. We found no evidence for a statistically significant or clinically important difference between NSAIDs or radiation in preventing HO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.