ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2010
FRAX assessment of osteoporotic fracture probability in Switzerland.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 4 of them syntheses that pooled it.
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55 citing papers in PubMed, 4 syntheses or guidelines pooled it, 114 citations in OpenAlex.
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- European guidance for the diagnosis and management of osteoporosis in postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Guideline
- A framework for the development of guidelines for the management of glucocorticoid-induced osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Pooled it
- Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011Pooled it
- Dietary and supplemental calcium intake and bone changes during antiresorptive osteoporosis treatment in older women: a longitudinal observational study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Sex- and site-specific reference data for size-invariant properties using multi-stack HRpQCT.JBMR plus · 2026Article
- Decomposing and simplifying the Fracture Risk Assessment Tool-a module from the Taiwan-specific calculator.JBMR plus · 2024Article
- Evaluation of Bone Turnover Markers Such as Osteoprotegerin, Sclerostin and Dickkopf-1 in Subclinical Hyperthyroidism.Indian journal of clinical biochemistry : IJCB · 2024Article
- The osteoporosis treatment gap in Switzerland between 1998 and 2018.Archives of osteoporosis · 2023Article
- Two Key Symptoms for Detecting Vertebral Compression Fracture among Elderly People with Acute Low Back Pain.Spine surgery and related research · 2022Article
- Article
- Risk Factors, Manifestation, and Awareness of Osteoporosis among Patients of Various Specialists in Switzerland: Results of a National Survey.Healthcare (Basel, Switzerland) · 2022Article
- FRAX-based fracture probabilities in South Africa.Archives of osteoporosis · 2021Article
- A surrogate FRAX model for Pakistan.Archives of osteoporosis · 2021Article
- Epidemiology of hip fracture and the development of a FRAX model for Uzbekistan.Archives of osteoporosis · 2020Article
- Epidemiology of osteoporotic fracture in Kazakhstan and development of a country specific FRAX model.Archives of osteoporosis · 2020Article
- Epidemiology of hip fractures in Bulgaria: development of a country-specific FRAX model.Archives of osteoporosis · 2020Article
- Epidemiology of osteoporotic fracture in Moldova and development of a country-specific FRAX model.Archives of osteoporosis · 2020Article
- A brief history of FRAX.Archives of osteoporosis · 2018Review
- Fermented dairy products consumption is associated with attenuated cortical bone loss independently of total calcium, protein, and energy intakes in healthy postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryA Swiss-specific FRAX model was developed. Patient profiles at increased probability of fracture beyond currently accepted reimbursement thresholds for bone mineral density (BMD) measurement by dual X-ray absorptiometry (DXA), and osteoporosis treatment were identified.
introductionThis study aimed to determine which constellations of clinical risk factors, alone, or combined with BMD measurement by DXA, contribute to improved identification of Swiss patients with increased probability of fracture.
methodsThe 10-year probability of hip and any major osteoporotic fracture was computed for both sexes, based on Swiss epidemiological data, integrating fracture risk and death hazard, in relation to validated clinical risk factors, with and without BMD values.
resultsFracture probability increased with age, lower body mass index (BMI), decreasing BMD T-score, and all clinical risk factors used alone or combined. Several constellations of risk factor profiles were identified, indicating identical or higher absolute fracture probability than risk factors currently accepted for DXA reimbursement in Switzerland. With identical sex, age and BMI, subjects with parental history of hip fracture had as high a probability of any major osteoporotic fracture as patients on oral glucocorticoids or with a prevalent fragility fracture. The presence of additional risk factors further increased fracture probability.
conclusionsThe customised FRAX model indicates that a shift from the current DXA-based intervention paradigm, toward a fracture risk continuum based on the 10-year probability of any major osteoporotic fracture may improve identification of patients at increased fracture risk.
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