ArticleVirchows Archiv : an international journal of pathology2009
Structural changes in the epithelium of the small intestine and immune cell infiltration of enteric ganglia following acute mucosal damage and local inflammation.
Article in Virchows Archiv : an international journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs) and Small Intestinal Submucosa (SIS) Hydrogel Composite Can Meliorate TNBS-Induced Experimental Colitis Through Regulating Inhibiting Macrophage Polarization Toward the M1 Phenotype.Mediators of inflammation · 2026Article
- Physical Exercise Alleviates Oxidative Stress and Autonomic Dysregulation in a Rat Model of Inflammatory Bowel Disease.Antioxidants (Basel, Switzerland) · 2025Article
- Impact of electro-acupuncture on EAAT2 and NMDAR-2B expression in goats with visceral hypersensitivity.Heliyon · 2024Article
- Investigation of Possible Positive Effects of Arbutin Application in Experimental Colitis Model.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Article
- Potent CCR3 Receptor Antagonist, SB328437, Suppresses Colonic Eosinophil Chemotaxis and Inflammation in theInternational journal of molecular sciences · 2022Article
- Effect of TNBS-induced colitis on enteric neuronal subpopulations in adult zebrafish.European journal of histochemistry : EJH · 2020Article
- Transmural impedance detects graded changes of inflammation in experimental colitis.Royal Society open science · 2020Article
- Anti-inflammatory Effects of Abdominal Vagus Nerve Stimulation on Experimental Intestinal Inflammation.Frontiers in neuroscience · 2019Article
- Colonic inflammation affects myenteric alpha-synuclein in nonhuman primates.Journal of inflammation research · 2019Article
- An objectiveRoyal Society open science · 2018Article
- The neuroprotective effects of human bone marrow mesenchymal stem cells are dose-dependent in TNBS colitis.Stem cell research & therapy · 2017Article
- Post-inflammatory Ileitis Induces Non-neuronal Purinergic Signaling Adjustments of Cholinergic Neurotransmission in the Myenteric Plexus.Frontiers in pharmacology · 2017Article
- A novel model for studying ileitis-induced visceral hypersensitivity in goats.Acta veterinaria Scandinavica · 2016Article
- Effects of Oxaliplatin Treatment on the Enteric Glial Cells and Neurons in the Mouse Ileum.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Eosinophils Contribute to Intestinal Inflammation via Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, in Experimental Crohn's Disease.Journal of Crohn's & colitis · 2016Article
- Sacral nerve stimulation enhances early intestinal mucosal repair following mucosal injury in a pig model.The Journal of physiology · 2016Article
- Visceral Hypersensitivity Is Provoked by 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Ileitis in Rats.Frontiers in pharmacology · 2016Article
- Allogeneic guinea pig mesenchymal stem cells ameliorate neurological changes in experimental colitis.Stem cell research & therapy · 2015Article
- Human adult stem cells derived from adipose tissue and bone marrow attenuate enteric neuropathy in the guinea-pig model of acute colitis.Stem cell research & therapy · 2015Article
- Differential effects of experimental ulcerative colitis on P2X7 receptor expression in enteric neurons.Histochemistry and cell biology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An acute enteritis is commonly followed by intestinal neuromuscular dysfunction, including prolonged hyperexcitability of enteric neurons. Such motility disorders are associated with maintained increases in immune cells adjacent to enteric ganglia and in the mucosa. However, whether the commonly used animal model, trinitrobenzene sulphonate (TNBS)-induced enteritis, causes histological and immune cell changes similar to human enteric neuropathies is not clear. We have made a detailed study of the mucosal damage and repair and immune cell invasion following intralumenal administration of TNBS. Intestines from untreated, sham-operated and TNBS-treated animals were examined at 3 h to 56 days. At 3 h, the mucosal surface was completely ablated, by 6 h an epithelial covering was substantially restored and by 1 day there was full re-epithelialisation. The lumenal epithelium developed from a squamous cell covering to a fully differentiated columnar epithelium with mature villi at about 7 days. Prominent phagocytic activity of enterocytes occurred at 1-7 days. A surge of eosinophils and T lymphocytes associated with the enteric nerve ganglia occurred at 3 h to 3 days. However, elevated immune cell numbers occurred in the lamina propria of the mucosa until 56 days, when eosinophils were still three times normal. We conclude that the disruption of the mucosal surface that causes TNBS-induced ileitis is brief, a little more than 6 h, and causes a transient immune cell surge adjacent to enteric ganglia. This is much briefer than the enteric neuropathy that ensues. Ongoing mucosal inflammatory reaction may contribute to the persistence of enteric neuropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.