Evidence map›Paper›PMID 19517070›Full record

ReviewDer Anaesthesist2009

[Pathophysiology of acute lung injury in severe burn and smoke inhalation injury].

M O Maybauer, S Rehberg, D L Traber, D N Herndon, D M Maybauer

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Der Anaesthesist, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01454869 (Efficacy of Heparin Nebulization on Lung Injury Score in Inhalation Burn Injury), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01454869 phase3withdrawnnot on this mapstarted 2012, after this paper: background citation

Efficacy of Heparin Nebulization on Lung Injury Score in Inhalation Burn Injury

TypeinterventionalSponsorTehran University of Medical SciencesRan2012 to 2014Enrolled0ConditionsHeparinArmsstandard care, Heparin
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. [Pay attention to burn rehabilitation assessment].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023
    Article
  3. Small animal models of thermal injury.Methods in cell biology · 2022
    Review
  4. Article
  5. Smoke Inhalation Injury: Etiopathogenesis, Diagnosis, and Management.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2018
    Review
  6. Article
  7. Article
  8. Article
  9. Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury.American journal of physiology. Lung cellular and molecular physiology · 2010
    Article
  10. [Inhalation injury--epidemiology, diagnosis and therapy].Wiener klinische Wochenschrift · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

M O MaybauerDepartment of Anesthesiology, Division of Critical Care Medicine, University of Texas Medical Branch and Shriners Burns Hospital for Children at Galveston, Galveston, Texas 77555-0591, USA. momaybau@utmb.edu
S Rehberg
D L Traber
D N Herndon
D M Maybauer
Shriners Hospitals for Children - Galveston · USPhilipps University of Marburg · DEThe University of Texas Medical Branch at Galveston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review article describes the pathophysiological aspects of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), induced by combined burn and smoke inhalation and examines various therapeutic approaches. The injury results in a fall in arterial oxygenation as a result of airway obstruction, increased pulmonary transvascular fluid flux and loss of hypoxic pulmonary vasoconstriction. The changes in cardiopulmonary function are mediated by reactive oxygen and nitrogen species. Nitric oxide (NO) is generated by both inducible and constitutive isoforms of nitric oxide synthase (NOS). Recently, neuronal NOS emerged as a major component within the pathogenesis of ARDS. NO rapidly combines with the oxygen radical superoxide to form reactive and highly toxic nitrogen species such as peroxynitrite. The control of NO formation involves poly(ADP-ribose) polymerase and its ability to up-regulate the activity of nuclear transcription factors through ribosylation. In addition, present data support a major role of the bronchial circulation in the injury, as blockage of bronchial blood flow will also minimize the pulmonary injury. Current data suggest that cytotoxins and activated cells are formed in the airway and carried to the parenchyma.

Indexed as

Acute Lung InjuryBronchiBurns, InhalationHumansPulmonary AlveoliPulmonary CirculationRespiratory Distress SyndromeSmoke Inhalation InjuryTrachea

Identifiers

PMID19517070
OpenAlexW1510588152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.