ArticleCurrent genomics2008
Genomic instability and carcinogenesis: an update.
Article in Current genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
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- Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A.International journal of molecular sciences · 2022Article
- Emerging role of caldesmon in cancer: A potential biomarker for colorectal cancer and other cancers.World journal of gastrointestinal oncology · 2022Review
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- Expanding the phenotype of E318K (c.952G > A) MITF germline mutation carriers: case series and review of the literature.Hereditary cancer in clinical practice · 2021Article
- Mining Natural Products with Anticancer Biological Activity through a Systems Biology Approach.Oxidative medicine and cellular longevity · 2021Article
- Cutaneous Melanoma Classification: The Importance of High-Throughput Genomic Technologies.Frontiers in oncology · 2021Review
- Oncogenic Potential of Bisphenol A and Common Environmental Contaminants in Human Mammary Epithelial Cells.International journal of molecular sciences · 2020Article
- Cancer-stromal cell fusion as revealed by fluorescence protein tracking.The Prostate · 2020Article
- The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy.Current molecular pharmacology · 2019Review
- Migration of mitochondrial DNA in the nuclear genome of colorectal adenocarcinoma.Genome medicine · 2017Article
- Regulation of DNA repair by non-coding miRNAs.Non-coding RNA research · 2016Review
- Effect of dedifferentiation on time to mutation acquisition in stem cell-driven cancers.PLoS computational biology · 2014Article
- Article
- A mathematical methodology for determining the temporal order of pathway alterations arising during gliomagenesis.PLoS computational biology · 2012Article
- A model for random genetic damage directing selection of diploid or aneuploid tumours.Cell proliferation · 2011Article
- Gene expression signature discriminates sporadic from post-radiotherapy-induced thyroid tumors.Endocrine-related cancer · 2011Article
- Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa.BMC biology · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancers arise as a result of stepwise accumulation of mutations which may occur at the nucleotide level and/or the gross chromosomal level. Many cancers particularly those of the colon display a form of genomic instability which may facilitate and speed up tumor initiation and development. In few instances, a "mutator mutation" has been clearly implicated in driving the accumulation of other carcinogenic mutations. For example, the post-replicative DNA mismatch repair deficiency results in dramatic increase in insertion/deletion mutations giving rise to the microsatellite instability (MSI) phenotype and may predispose to a spectrum of tumours when it occurs in the germline. Although many sporadic cancers show multiple mutations suggesting unstable genome, the role of this instability in carcinogenesis, as opposed to the power of natural selection, has been a matter of controversy. This review gives an update of the latest data on these issues particularly recent data from genome-wide, high throughput techniques as well as mathematical modelling. Throughout this review, reference will be made to the relevance of genomic instability to the pathogenesis of colorectal carcinoma particularly its hereditary and familial subsets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.