ArticleThe open ophthalmology journal2008
Expression of p16 in conjunctival intraepithelial neoplasia does not correlate with HPV-infection.
Article in The open ophthalmology journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis.British journal of cancer · 2013Pooled it
- EZH2 expression in corneal and conjunctival intraepithelial neoplasia and squamous cell carcinoma: a potential marker for diagnosis.International ophthalmology · 2025Article
- Epstein-Barr Virus, But Not Human Papillomavirus, Is Associated With Preinvasive and Invasive Ocular Surface Squamous Neoplasias in Zambian Patients.Frontiers in oncology · 2022Article
- Review
- [Conjunctival malignancies].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019Article
- Human Papilloma Virus Vaccination and Incidence of Ocular Surface Squamous Neoplasia.International ophthalmology clinics · 2017Review
- Expression of p16 and p53 in Intraepithelial Periocular Sebaceous Carcinoma.Ocular oncology and pathology · 2015Article
- Human Papilloma Virus Infection Does Not Predict Response to Interferon Therapy in Ocular Surface Squamous Neoplasia.Ophthalmology · 2015Article
- Correlation of EGFR, pEGFR and p16INK4 expressions and high risk HPV infection in HIV/AIDS-related squamous cell carcinoma of conjunctiva.Infectious agents and cancer · 2014Article
- Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia.Eye (London, England) · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of our study was to identify the frequency of expression of p16(INK4a) (CDKN2A) and HPV (human papilloma virus) in different grades of conjunctival intraepithelial neoplasia (CIN).Twelve specimens including CIN I (2), II (3), III (5), and CIN with beginning invasion (2), as well as 15 control specimens, were stained with antibodies against p16(INK4a) and MIB1. The presence of HPV was examined by PCR.p16 as well as MIB1 were significantly elevated in CIN compared to control specimens (p<0.01) without correlation with the differentiation grade. Only two cases with CIN grade 3 contained HPV 16.As few control specimens also showed increased p16(INK4a) expression, p16(INK4a) seems not to be a very reliable marker for the exact determination of CIN. It could serve as an additional diagnostic tool besides the morphological characterization. Our study suggested that p16(INK4a) elevation is not associated with HPV infection.
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Registered trials
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