ArticleThe American journal of pathology1991
Cytokine expression in T-cell lymphomas and Hodgkin's disease. Its possible implication in autocrine or paracrine production as a potential basis for neoplastic growth.
Article in The American journal of pathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 97 citations in OpenAlex.
- Life stress, mood disturbance, and elevated interleukin-6 in healthy older women.The journals of gerontology. Series A, Biological sciences and medical sciences · 1999Trial
- Article
- Classic Hodgkin lymphoma and Castleman disease: an entity appears to be emerging.Virchows Archiv : an international journal of pathology · 2020Article
- Sarcomatoid variant of ALK- anaplastic large cell lymphoma involving multiple lymph nodes and both lungs with production of proinflammatory cytokines: report of a case and review of literature.International journal of clinical and experimental pathology · 2014Review
- Article
- [Anaplastic large cell lymphoma and keratoacanthoma].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2004Article
- Expression of functional interleukin-3 receptors on Hodgkin and Reed-Sternberg cells.The American journal of pathology · 2002Article
- Pseudoautosomal linkage of Hodgkin disease.American journal of human genetics · 1999Article
- Differential cytokine expression in EBV positive peripheral T cell lymphomas.Molecular pathology : MP · 1999Article
- Adrenal enlargement and failure of suppression of circulating cortisol by dexamethasone in patients with malignancy.British journal of cancer · 1999Article
- Human interleukin-10 expression in T/natural killer-cell lymphomas: association with anaplastic large cell lymphomas and nasal natural killer-cell lymphomas.The American journal of pathology · 1998Article
- Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The role of interleukin-6 in certain age-related diseases.Drugs & aging · 1994Review
- CD40 expression in Hodgkin's disease.The American journal of pathology · 1994Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The detection of an increasing number of cytokines and the demonstration of autocrine and paracrine mechanisms perpetuating tumor growth prompted the investigation of the expression of the cytokines IL-2, IL-3, IL-4, IL-5, IL-6, IFN gamma, Tac, and GMCSF in primary lymph-node biopsies of patients with peripheral T-cell lymphoma (n = 11), Hodgkin's disease (n = 13), and large-cell anaplastic lymphoma (n = 6) by means of Northern blot analysis and in situ hybridization (ISH); 15 of 28 cases had IL-6 message, predominantly in cases of Hodgkin's disease (HD) and large-cell anaplastic lymphomas (LCAL). Interferon gamma was found in about 50% of the cases among all entities. Other cytokine expression was rare except two cases of HD with high amounts of IL-4 mRNA. These results indicate that large amounts of growth factor transcripts are present in a variety of malignant lymphomas. The meaning of this expression is still unclear. It may be a loss of physiologic regulation within the cytokine network which may thus influence neoplastic cell growth as some cases have a quantity of cytokine expression which is similar or even above that of stimulated T cells. ISH demonstrates in individual cases that the expression is at least in part due to malignant cells.
Indexed as
Identifiers
1951632PMC1886335W2136537680What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.