ArticleJournal of neurophysiology2009
Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant mice.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Selective Lis1 inactivation disrupts migration and positioning of cortical somatostatin interneurons.Scientific reports · 2026Article
- Altered extracellular matrix structure and elevated stiffness in a brain organoid model for disease.Nature communications · 2025Article
- Levetiracetam Prevents Neurophysiological Changes and Preserves Cognitive Function in the Human Immunodeficiency Virus (HIV)-1 Transactivator of Transcription Transgenic Mouse Model of HIV-Associated Neurocognitive Disorder.The Journal of pharmacology and experimental therapeutics · 2024Article
- Abnormalities in Cortical GABAergic Interneurons of the Primary Motor Cortex Caused byFrontiers in cell and developmental biology · 2022Article
- Article
- PAFAH1B1 haploinsufficiency disrupts GABA neurons and synaptic E/I balance in the dentate gyrus.Scientific reports · 2017Article
- Microtubule plus-end tracking proteins in neuronal development.Cellular and molecular life sciences : CMLS · 2016Review
- Neuronal migration and its disorders affecting the CA3 region.Frontiers in cellular neuroscience · 2014Review
- LIS1 and DCX: Implications for Brain Development and Human Disease in Relation to Microtubules.Scientifica · 2013Review
- LIS1 deficiency promotes dysfunctional synaptic integration of granule cells generated in the developing and adult dentate gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Complex control of GABA(A) receptor subunit mRNA expression: variation, covariation, and genetic regulation.PloS one · 2012Article
- A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons.Journal of neurophysiology · 2011Article
- Role of cytoskeletal abnormalities in the neuropathology and pathophysiology of type I lissencephaly.Acta neuropathologica · 2011Review
- Balance of inhibitory and excitatory synaptic activity is altered in fast-spiking interneurons in experimental cortical dysplasia.Journal of neurophysiology · 2009Article
- The Course of Inhibition Never Did Run Smooth: Parvalbumin Interneuron Dysfunction in a Mouse Model of Lissencephaly.Epilepsy currentsArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Epilepsy and brain malformation are commonly associated with excessive synaptic excitation and decreased synaptic inhibition of principal neurons. However, few studies have examined the state of synaptic inhibition of interneurons in an epileptic, malformed brain. We analyzed inhibitory inputs, mediated by gamma-aminobutyric acid (GABA), to hippocampal interneurons in a mouse model of type 1 lissencephaly, a neurological disorder linked with severe seizures and brain malformation. In the disorganized hippocampal area CA1 of Lis1(+/-) mice, we initially observed a selective displacement of fast-spiking, parvalbumin-positive basket-type interneurons from stratum oriens (SO) locations to s. radiatum and s. lacunosum-moleculare (R/LM). Next, we recorded spontaneous and miniature inhibitory postsynaptic currents (sIPSCs and mIPSCs) onto visually identified interneurons located in SO or R/LM of Lis1(+/-) mice and age-matched littermate controls. We observed significant, layer-specific reorganizations in GABAergic inhibition of interneurons in Lis1 mutant mice. Spontaneous IPSC frequency onto SO interneurons was significantly increased in hippocampal slices from Lis1(+/-) mice, whereas mIPSC mean amplitude onto these interneurons was significantly decreased. In addition, the weighted decay times of sIPSCs and mIPSCs were significantly increased in R/LM interneurons. Taken together, these findings illustrate the extensive redistribution and reorganization of inhibitory connections between interneurons that can take place in a malformed brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.