ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Robust short-latency perisomatic inhibition onto neocortical pyramidal cells detected by laser-scanning photostimulation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
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- Direct Electrical Stimulation in Electrocorticographic Brain-Computer Interfaces: Enabling Technologies for Input to Cortex.Frontiers in neuroscience · 2019Review
- Gabapentin Prevents Progressive Increases in Excitatory Connectivity and Epileptogenesis Following Neocortical Trauma.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Studies of cortical connectivity using optical circuit mapping methods.The Journal of physiology · 2018Review
- Response Properties of Interneurons and Pyramidal Neurons in Macaque MSTd and VPS Areas During Self-Motion.Frontiers in neural circuits · 2018Article
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- Mapping human brain networks with cortico-cortical evoked potentials.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- Excitatory and inhibitory synaptic connectivity to layer V fast-spiking interneurons in the freeze lesion model of cortical microgyria.Journal of neurophysiology · 2014Article
- Spatial pattern of intra-laminar connectivity in supragranular mouse auditory cortex.Frontiers in neural circuits · 2014Article
- The roles of monkey M1 neuron classes in movement preparation and execution.Journal of neurophysiology · 2013Article
- Visual experience and subsequent sleep induce sequential plastic changes in putative inhibitory and excitatory cortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Independent transmission of convergent visceral primary afferents in the solitary tract nucleus.Journal of neurophysiology · 2013Article
- Low-fidelity GABA transmission within a dense excitatory network of the solitary tract nucleus.The Journal of physiology · 2012Article
- Circuit mapping by ultraviolet uncaging of glutamate.Cold Spring Harbor protocols · 2012Article
- Laminarly orthogonal excitation of fast-spiking and low-threshold-spiking interneurons in mouse motor cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Changing microcircuits in the subplate of the developing cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Increased excitatory synaptic input to granule cells from hilar and CA3 regions in a rat model of temporal lobe epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The columnar and laminar organization of inhibitory connections to neocortical excitatory cells.Nature neuroscience · 2011Article
- Enhanced infragranular and supragranular synaptic input onto layer 5 pyramidal neurons in a rat model of cortical dysplasia.Cerebral cortex (New York, N.Y. : 1991) · 2010Article
- Computational modeling of GABAA receptor-mediated paired-pulse inhibition in the dentate gyrus.Journal of computational neuroscience · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Inhibitory connectivity onto neocortical pyramidal cells was mapped using LSPS (laser-scanning photostimulation/glutamate uncaging). The average onset latency of IPSCs was shorter than that of EPSCs recorded in the same cells, indicating a specific mechanism for rapid network recruitment of inhibition. The majority of strong inhibitory synaptic inputs originated within 300 mum of the recorded cell's soma, had onset latencies between 4 and 10 ms, and high amplitude [short-latency IPSCs (slIPSCs)]. slIPSCs were GABA(A) receptor- mediated chloride currents that were evoked in an all-or-none manner. We tested whether slIPSCs resulted from somatic depolarization of presynaptic interneurons or from direct excitation of inhibitory presynaptic terminals via kainate receptors. Our evidence supports the former hypothesis: (1) slIPSCs had similar sensitivity to kainate and AMPA receptor blockers as electrically evoked EPSCs. (2) slIPSCs frequently had an notched rising phase suggestive of summated IPSCs resulting from repetitive firing of presynaptic neurons. (3) Latencies and interevent intervals were consistent with spike latencies and interspike intervals in fast-spiking (FS) interneurons. (4) slIPSCs were frequently evoked at spots where the recorded cell was also excited directly, but approximately 15% of spots from which slIPSCs were evoked did not overlap with the recorded neuron's cell body. We propose that slIPSCs from FS interneurons represent a pool of powerful inhibitory signals that can be recruited by local excitation. Because of their magnitude, progressive recruitment, and short latency, slIPSCs are a effective mechanism of regulating excitability in neocortical circuits.
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