ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
ZHX2 Interacts with Ephrin-B and regulates neural progenitor maintenance in the developing cerebral cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Cooperative regulation of Zhx1 and hnRNPA1 drives the cardiac progenitor-specific transcriptional activation during cardiomyocyte differentiation.Cell death discovery · 2023Article
- Article
- Zhx2 Is a Candidate Gene Underlying Oxymorphone Metabolite Brain Concentration Associated with State-Dependent Oxycodone Reward.The Journal of pharmacology and experimental therapeutics · 2022Article
- ZHX2 in health and disease.Frontiers in oncology · 2022Review
- Microarray Genotyping Identifies New Loci Associated with Dementia in Parkinson's Disease.Genes · 2021Article
- Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.Frontiers in molecular neuroscience · 2021Article
- The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases.Kidney international · 2020Article
- Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Axon guidance pathways and the control of gene expression.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1.Oncogene · 2018Article
- Zbtb20 promotes astrocytogenesis during neocortical development.Nature communications · 2016Article
- Exome sequencing reveals a high genetic heterogeneity on familial Hirschsprung disease.Scientific reports · 2015Article
- Zinc fingers and homeoboxes family in human diseases.Cancer gene therapy · 2015Review
- Analysis of adult cerebral cortex and hippocampus transcriptomes reveals unique molecular changes in the Ts1Cje mouse model of down syndrome.Brain pathology (Zurich, Switzerland) · 2015Article
- EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun N-terminal kinase (JNK) activation.The Journal of biological chemistry · 2014Article
- Beyond boundaries--Eph:ephrin signaling in neurogenesis.Cell adhesion & migration · 2014Review
- Regulation of cell differentiation by Eph receptor and ephrin signaling.Cell adhesion & migration · 2014Review
- Eph receptor signaling and ephrins.Cold Spring Harbor perspectives in biology · 2013Review
- Article
- Non-SH2/PDZ reverse signaling by ephrins.Seminars in cell & developmental biology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Neural progenitor cells in the ventricular zone of the developing mammalian cerebral cortex give rise to specialized cortical cell types via consecutive rounds of proliferation and differentiation, but the mechanisms by which progenitor cell self-renewal and differentiation are regulated during cortical development are not well understood. Here, we show that zinc-finger and homeodomain protein 2 (ZHX2) is specifically expressed in neural progenitor cells during cortical neurogenesis. ZHX2 binds to the cytoplasmic domain of ephrin-B1, which is expressed in cortical neural progenitors and plays a role in neural progenitor cell maintenance. ZHX2 acts as a transcriptional repressor in cell, and its repressor activity is enhanced by coexpression of an ephrin-B1 intracellular domain. Blocking ZHX2 function in cultured neural progenitor cells or in the embryonic cortex causes neuronal differentiation, whereas overexpression of ZHX2 and an ephrin-B1 intracellular domain disrupts the normal differentiation of cortical neural progenitor cells. This study identifies ZHX2 as a novel regulator of neural progenitor cell maintenance and suggests a potential nuclear mechanism of the ephrin-B function in the cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.