ArticleProceedings of the National Academy of Sciences of the United States of America2009
Inter-sarcomere coordination in muscle revealed through individual sarcomere response to quick stretch.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- A song of heads and tails: myosin II conformational regulation and filament dynamics shape force generation in non-muscle cells.Biophysical reviews · 2026Review
- Structured neighboring-sarcomere switching is coupled to variable-reach internal length redistribution during hyperthermal sarcomeric oscillations in living cardiomyocytes.Biophysics and physicobiology · 2026Article
- Impact of stretch on sarcomere length variability in isolated fully relaxed rat cardiac myocytes.Pflugers Archiv : European journal of physiology · 2023Article
- Impact of stretch on sarcomere length variability in isolated fully relaxed rat cardiac myocytes.Research square · 2023Article
- Contractile State Dependent Sarcomere Length Variability in Isolated Guinea-Pig Cardiomyocytes.Frontiers in physiology · 2022Article
- Synchrony of sarcomeric movement regulates left ventricular pump function in the in vivo beating mouse heart.The Journal of general physiology · 2021Article
- Nanoscopic changes in the lattice structure of striated muscle sarcomeres involved in the mechanism of spontaneous oscillatory contraction (SPOC).Scientific reports · 2020Article
- Extraction of Thick Filaments in Individual Sarcomeres Affects Force Production by Single Myofibrils.Biophysical journal · 2020Article
- Calcium-dependent titin-thin filament interactions in muscle: observations and theory.Journal of muscle research and cell motility · 2020Review
- Does partial titin degradation affect sarcomere length nonuniformities and force in active and passive myofibrils?American journal of physiology. Cell physiology · 2018Article
- Microfluidic perfusion shows intersarcomere dynamics within single skeletal muscle myofibrils.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Increases of desmin and α-actinin in mouse cardiac myofibrils as a response to diastolic dysfunction.Journal of molecular and cellular cardiology · 2016Article
- Model simulation of the SPOC wave in a bundle of striated myofibrils.Biophysics and physicobiology · 2016Article
- Spontaneous oscillatory contraction (SPOC) in cardiomyocytes.Biophysical reviews · 2015Article
- Sarcomere lengths in human extensor carpi radialis brevis measured by microendoscopy.Muscle & nerve · 2013Article
- The effects of Ca2+ and MgADP on force development during and after muscle length changes.PloS one · 2013Article
- Residual force enhancement in skeletal muscles: one sarcomere after the other.Journal of muscle research and cell motility · 2012Review
- Microneedle-based analysis of the micromechanics of the metaphase spindle assembled in Xenopus laevis egg extracts.Nature protocols · 2012Article
- Is titin a 'winding filament'? A new twist on muscle contraction.Proceedings. Biological sciences · 2012Article
- Substrate stiffness increases twitch power of neonatal cardiomyocytes in correlation with changes in myofibril structure and intracellular calcium.Biophysical journal · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The force generation and motion of muscle are produced by the collective work of thousands of sarcomeres, the basic structural units of striated muscle. Based on their series connection to form a myofibril, it is expected that sarcomeres are mechanically and/or structurally coupled to each other. However, the behavior of individual sarcomeres and the coupling dynamics between sarcomeres remain elusive, because muscle mechanics has so far been investigated mainly by analyzing the averaged behavior of thousands of sarcomeres in muscle fibers. In this study, we directly measured the length-responses of individual sarcomeres to quick stretch at partial activation, using micromanipulation of skeletal myofibrils under a phase-contrast microscope. The experiments were performed at ADP-activation (1 mM MgATP and 2 mM MgADP in the absence of Ca(2+)) and also at Ca(2+)-activation (1 mM MgATP at pCa 6.3) conditions. We show that under these activation conditions, sarcomeres exhibit 2 distinct types of responses, either "resisting" or "yielding," which are clearly distinguished by the lengthening distance of single sarcomeres in response to stretch. These 2 types of sarcomeres tended to coexist within the myofibril, and the sarcomere "yielding" occurred in clusters composed of several adjacent sarcomeres. The labeling of Z-line with anti-alpha-actinin antibody significantly suppressed the clustered sarcomere "yielding." These results strongly suggest that the contractile system of muscle possesses the mechanism of structure-based inter-sarcomere coordination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.