ArticleProceedings. Biological sciences2009
Signals of major histocompatibility complex overdominance in a wild salmonid population.
Article in Proceedings. Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Article
- A single genomic region involving a putative chromosome rearrangement in flat oyster (Evolutionary applications · 2022Article
- Article
- A brain and a head for a different habitat: Size variation in four morphs of Arctic charr (Ecology and evolution · 2020Article
- Article
- Article
- Combining molecular evolution and environmental genomics to unravel adaptive processes of MHC class IIB diversity in European minnows (Phoxinus phoxinus).Ecology and evolution · 2013Article
- Mhc supertypes confer both qualitative and quantitative resistance to avian malaria infections in a wild bird population.Proceedings. Biological sciences · 2013Article
- A sequence-based approach demonstrates that balancing selection in classical human leukocyte antigen (HLA) loci is asymmetric.Human molecular genetics · 2013Article
- MHC-I affects infection intensity but not infection status with a frequent avian malaria parasite in blue tits.PloS one · 2013Article
- Sex-specific selection for MHC variability in Alpine chamois.BMC evolutionary biology · 2012Article
- MHC signaling during social communication.Advances in experimental medicine and biology · 2012Article
- Varying disease-mediated selection at different life-history stages of Atlantic salmon in fresh water.Evolutionary applications · 2011Article
- MHC evolution in three salmonid species: a comparison between class II alpha and beta genes.Immunogenetics · 2010Article
- Genetic and potential non-genetic benefits increase offspring fitness of polyandrous females in non-resource based mating system.BMC evolutionary biology · 2010Article
- Does genetic diversity predict health in humans?PloS one · 2009Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major histocompatibility complex (MHC) contains the most variable genes in vertebrates, but despite extensive research, the mechanisms maintaining this polymorphism are still unresolved. One hypothesis is that MHC polymorphism is a result of balancing selection operating by overdominance, but convincing evidence for overdominant selection in natural populations has been lacking. We present strong evidence consistent with MHC-specific overdominance in a free-living population of Arctic charr (Salvelinus alpinus) in northernmost Europe. In this population, where just two MHC alleles were observed, MHC heterozygous fish had a lower parasite load, were in better condition (as estimated by a fatness indicator) and had higher survival under stress than either of the homozygotes. Conversely, there was no consistent association between these fitness measures and assumedly neutral microsatellite variability, indicating an MHC-specific effect. Our results provide convincing empirical evidence consistent with the notion that overdominance can be an important evolutionary mechanism contributing to MHC polymorphism in wild animal populations. They also support a recent simulation study indicating that the number of alleles expected to be maintained at an MHC loci can be low, even under strong heterozygote advantage.
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