ReviewCurrent opinion in immunology2009
B cell acquisition of antigen in vivo.
Review in Current opinion in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- B Cell Subsets and Atherosclerosis: Updates and Emerging Concepts.Immunological reviews · 2026Review
- Article
- Nanoparticle-based approaches to target the lymphatic system for antitumor treatment.Cellular and molecular life sciences : CMLS · 2021Review
- Acute Lymph Node Slices Are a Functional Model System to Study Immunity Ex Vivo.ACS pharmacology & translational science · 2021Article
- Expression of inhibitory receptors by B cells in chronic human infectious diseases restricts responses to membrane-associated antigens.Science advances · 2020Article
- Multi-Compartment 3D-Cultured Organ-on-a-Chip: Towards a Biomimetic Lymph Node for Drug Development.Pharmaceutics · 2020Article
- B cell memory: building two walls of protection against pathogens.Nature reviews. Immunology · 2020Review
- Material design for lymph node drug delivery.Nature reviews. Materials · 2019Article
- Linking signaling and selection in the germinal center.Immunological reviews · 2019Review
- Time to Micromanage the Pathogen-Host-Vector Interface: Considerations for Vaccine Development.Vaccines · 2019Review
- The Coordination Between B Cell Receptor Signaling and the Actin Cytoskeleton During B Cell Activation.Frontiers in immunology · 2018Review
- Type 1 Interferons and NK Cells Limit Murine Cytomegalovirus Escape from the Lymph Node Subcapsular Sinus.PLoS pathogens · 2016Article
- The Cellular Bases of Antibody Responses during Dengue Virus Infection.Frontiers in immunology · 2016Review
- Modes of Antigen Presentation by Lymph Node Stromal Cells and Their Immunological Implications.Frontiers in immunology · 2015Review
- The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation.Biochimica et biophysica acta · 2014Review
- A systems approach to designing next generation vaccines: combining α-galactose modified antigens with nanoparticle platforms.Scientific reports · 2014Article
- The actin cytoskeleton coordinates the signal transduction and antigen processing functions of the B cell antigen receptor.Frontiers in biology · 2013Article
- Immunization with recombinant prion protein leads to partial protection in a murine model of TSEs through a novel mechanism.PloS one · 2013Article
- The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs.Nature reviews. Immunology · 2010Review
- Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The fate of B lymphocytes is dictated in large part by cognate antigen and the environment in which it is encountered. Yet we are only now beginning to understand where and how B cells acquire antigen. Recent studies identify multiple pathways by which lymph-borne antigens enter the B cell follicles of LNs. Size is a major factor as particulate antigens and large IC are bound by subcapsular sinus macrophages. By contrast, small antigens (under 70kDa) are rapidly channeled into follicles via conduits secreted by fibroblastic reticular cells (FRC). Interestingly, the conduits not only deliver antigen to follicular dendritic cells (FDC) but also provide a rich source of B cell chemokine, that is, CXCL-13. Thus, the follicular conduits provide an 'antigen highway' for B cells trafficking within the LN. These new findings provide an important discovery in understanding how B cells acquire cognate antigen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.