ReviewJournal of gastrointestinal cancer2009
Interplay of tumor microenvironment cell types with parenchymal cells in pancreatic cancer development and therapeutic implications.
Review in Journal of gastrointestinal cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- A Cancer and Leukemia Group B phase II study of sunitinib malate in patients with previously treated metastatic pancreatic adenocarcinoma (CALGB 80603).The oncologist · 2010Trial
- Article
- Apoptosis and anergy of T cell induced by pancreatic stellate cells-derived galectin-1 in pancreatic cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Human Pancreatic Cancer-Associated Stellate Cells Remain Activated after in vivo Chemoradiation.Frontiers in oncology · 2014Article
- Necrotizing fasciitis in three university hospitals in Korea: a change in causative microorganisms and risk factors of mortality during the last decade.Infection & chemotherapy · 2013Article
- The role of stroma in pancreatic cancer: diagnostic and therapeutic implications.Nature reviews. Gastroenterology & hepatology · 2012Review
- How fibrosis influences imaging and surgical decisions in pancreatic cancer.Frontiers in physiology · 2012Article
- Mucin-based targeted pancreatic cancer therapy.Current pharmaceutical design · 2012Review
- Self-expanding metal stents for biliary drainage in patients with resectable pancreatic cancer: single-center experience with 79 cases.Digestive diseases and sciences · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
introductionThe process of "induction," namely, the formation of a tissue by the functional interaction between the epithelial layer and the stroma, is key for the development of many organs, in particular to the pancreas. DISCUSSION: In diseases like pancreatic cancer, most studies performed to date, in the area of pancreatic cancer, have focused on studying epithelial cells and their contribution to this disease. Strikingly, until recently, the stroma that surrounds cancer cells in pancreatic tumors (desmoplastic reaction-tumor microenvironment) has remained an underrepresented area of research. However, several laboratories are increasingly posing questions as what is the role of this tumor microenvironment in the development and progression of this fatal disease. Therefore, in the current article, we define and describe the components of this desmoplastic reaction and the pancreatic tumor microenvironment and briefly review advances being made. More importantly, we highlight the urgent need of research in this field.
conclusionWe anticipate that, because of the paucity of knowledge on this subject, studies on the pancreatic tumor microenvironment will bring new concepts which will ultimately impact in designing new diagnosis and treatment for this disease.
Indexed as
Identifiers
19513861What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.