ArticleDigestive diseases and sciences2010
Gastric hyposecretion in esophageal squamous-cell carcinomas.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Association of Serum Pepsinogens With Esophageal Squamous Cell Carcinoma Risk: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2022Pooled it
- Non-acid reflux and esophageal dysmotility is associated with early esophageal squamous cell carcinoma.Journal of cancer research and clinical oncology · 2023Article
- Relationship between Helicobacter Pylori Infection and the Risk of Esophageal Cancer in Thailand.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Inverse relations betweenWorld journal of gastrointestinal oncology · 2022Article
- Serum pepsinogen assay is not recommended for the diagnosis of esophageal squamous cell carcinoma: a systematic review and meta-analysis.Cancer management and research · 2019Article
- Systematic Review with Meta-analysis: Association of Helicobacter pylori Infection with Esophageal Cancer.Gastroenterology research and practice · 2019Review
- Circumferential distribution and clinical characteristics of esophageal cancer in lower esophagus: differences related to histological subtype.Esophagus : official journal of the Japan Esophageal Society · 2019Article
- Time series analysis of gastric acid secretion over a 20-year period in normal Japanese men.Journal of gastroenterology · 2015Article
- 24-Hour Measurement of Gastric pH in Rural South Africa.Gastroenterology research and practice · 2015Article
- Article
- Management of experimental hypochlorhydria with iron deficiency by the composite extract of Fumaria vaillantii L. and Benincasa hispida T. in rat.Journal of natural science, biology, and medicine · 2014Article
- Should peri-gastrectomy gastric acidity be our focus among gastric cancer patients?World journal of gastroenterology · 2014Article
- Atrophic gastritis: risk factor for esophageal squamous cell carcinoma in a Latin-American population.World journal of gastroenterology · 2013Article
- Gastric hypochlorhydria is associated with an exacerbation of dyspeptic symptoms in female patients.Journal of gastroenterology · 2013Article
- Epidemiology of esophageal cancer in Japan and China.Journal of epidemiology · 2013Review
- Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals.Gastroenterology · 2011Article
- Serum pepsinogens and Helicobacter pylori in relation to the risk of esophageal squamous cell carcinoma in the alpha-tocopherol, beta-carotene cancer prevention study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2010Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, gastric fundic atrophy is reported to be an independent risk factor for esophageal squamous-cell carcinoma (ESCC). The aim of this study is to investigate the acid secretory level in ESCC in a case-control study. From April 2004 to March 2008, 100 consecutive subjects with early ESCC and 100 age- and sex-matched asymptomatic controls were prospectively enrolled. Gastrin-stimulated acid output was assessed by endoscopic gastrin test. Conditional regression analyses were used to adjust for other potential confounders. Multivariate analyses revealed a strong association between profound hypochlorhydria and ESCC with odds ratio (95% confidence interval): 6.0 (1.9-18.4). The association remained significant after adjusting for the effect of gastric atrophy as a covariate. The association became stronger as the ESCC developed more distal site of the esophagus. This study indicates that profound hypochlorhydria is a strong independent risk factor for ESCC even after adjusting for the influence of gastric atrophy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.