ArticleJournal of the Association for Research in Otolaryngology : JARO2009
Dynamic displacement of normal and detached semicircular canal cupula.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Epley's Influence on Horizontal Canal BPPV Variants.Audiology research · 2025Review
- Modeling of magnetic vestibular stimulation experienced during high-field clinical MRI.Communications medicine · 2025Article
- Quantitative study on objective indicators for assessing motion sickness susceptibility based on Vestibulo-Ocular Reflex experiments.Scientific reports · 2024Article
- A Review of Neural Data and Modelling to Explain How a Semicircular Canal Dehiscence (SCD) Causes Enhanced VEMPs, Skull Vibration Induced Nystagmus (SVIN), and the Tullio Phenomenon.Audiology research · 2023Review
- Finite Element Modeling of Residual Hearing after Cochlear Implant Surgery in Chinchillas.Bioengineering (Basel, Switzerland) · 2023Article
- A mathematical model for mechanical activation and compound action potential generation by the utricle in response to sound and vibration.Frontiers in neurology · 2023Article
- Case report: Atypical patterns of nystagmus suggest posterior canal cupulolithiasis and short-arm canalithiasis.Frontiers in neurology · 2022Article
- Exploring the biomechanical responses of human cupula by numerical analysis of temperature experiments.Scientific reports · 2021Article
- Translations of Steinhausen's Publications Provide Insight Into Their Contributions to Peripheral Vestibular Neuroscience.Frontiers in neurology · 2021Review
- Unusual Vestibulo-Ocular Reflex Responses in Patients With Peripheral Vestibular Disorders Detected by the Caloric Step Stimulus Test.Frontiers in neurology · 2020Article
- Semicircular canal biomechanics in health and disease.Journal of neurophysiology · 2019Review
- Wave Mechanics of the Vestibular Semicircular Canals.Biophysical journal · 2017Article
- BODIPY-Conjugated Xyloside Primes Fluorescent Glycosaminoglycans in the Inner Ear of Opsanus tau.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- Multiple Time Courses of Vestibular Set-Point Adaptation Revealed by Sustained Magnetic Field Stimulation of the Labyrinth.Current biology : CB · 2016Article
- Form and function of the mammalian inner ear.Journal of anatomy · 2016Review
- Spatial orientation of the angular vestibulo-ocular reflex (aVOR) after semicircular canal plugging and canal nerve section.Experimental brain research · 2011Article
- Virtual labyrinth model of vestibular afferent excitation via implanted electrodes: validation and application to design of a multichannel vestibular prosthesis.Experimental brain research · 2011Article
- Infrared photostimulation of the crista ampullaris.The Journal of physiology · 2011Article
- Sitting-up vertigo and trunk retropulsion in patients with benign positional vertigo but without positional nystagmus.Journal of neurology, neurosurgery, and psychiatry · 2011Article
- Mechanical amplification by hair cells in the semicircular canals.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The dynamic displacement of the semicircular canal cupula and modulation of afferent nerve discharge were measured simultaneously in response to physiological stimuli in vivo. The adaptation time constant(s) of normal cupulae in response to step stimuli averaged 36 s, corresponding to a mechanical lower corner frequency for sinusoidal stimuli of 0.0044 Hz. For stimuli equivalent to 40-200 deg/s of angular head velocity, the displacement gain of the central region of the cupula averaged 53 nm per deg/s. Afferents adapted more rapidly than the cupula, demonstrating the presence of a relaxation process that contributes significantly to the neural representation of angular head motions by the discharge patterns of canal afferent neurons. We also investigated changes in time constants of the cupula and afferents following detachment of the cupula at its apex-mechanical detachment that occurs in response to excessive transcupular endolymph pressure. Detached cupulae exhibited sharply reduced adaptation time constants (300 ms-3 s, n = 3) and can be explained by endolymph flowing rapidly over the apex of the cupula. Partially detached cupulae reattached and normal afferent discharge patterns were recovered 5-7 h following detachment. This regeneration process may have relevance to the recovery of semicircular canal function following head trauma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.