ArticleJournal of exposure science & environmental epidemiology2010
Plasma organochlorine levels and prostate cancer risk.
Article in Journal of exposure science & environmental epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Body concentrations of persistent organic pollutants and prostate cancer: a meta-analysis.Environmental science and pollution research international · 2015Pooled it
- Breast and prostate glands affected by environmental substances (Review).Oncology reports · 2021Review
- Testosterone and prostate health: Have the paradigms truly shifted?Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2020Article
- Occupational Risk Factors for Prostate Cancer: A Meta-analysis.Journal of cancer prevention · 2019Review
- Toxicokinetics of chiral polychlorinated biphenyls across different species--a review.Environmental science and pollution research international · 2016Review
- EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.Endocrine reviews · 2015Review
- Prediagnostic Serum Organochlorine Concentrations and Metastatic Prostate Cancer: A Nested Case-Control Study in the Norwegian Janus Serum Bank Cohort.Environmental health perspectives · 2015Article
- Associations of plasma concentrations of dichlorodiphenyldichloroethylene and polychlorinated biphenyls with prostate cancer: a case-control study in Guadeloupe (French West Indies).Environmental health perspectives · 2015Article
- Exposure to endocrine disrupting chemicals and male reproductive health.Frontiers in public health · 2014Review
- High-performance metabolic profiling with dual chromatography-Fourier-transform mass spectrometry (DC-FTMS) for study of the exposome.Metabolomics : Official journal of the Metabolomic Society · 2013Article
- Actions of estrogens and endocrine disrupting chemicals on human prostate stem/progenitor cells and prostate cancer risk.Molecular and cellular endocrinology · 2012Review
- Folate intake, alcohol consumption, and the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism: influence on prostate cancer risk and interactions.Frontiers in oncology · 2012Article
- An update of cancer incidence in the Agricultural Health Study.Journal of occupational and environmental medicine · 2010Article
- Association Between a Dietary Inflammatory Index and Prostate Cancer Risk in Ontario, Canada.Nutrition and cancerArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
A case-control study was conducted to determine the association between plasma organochlorine levels and prostate cancer risk. Male clinic patients scheduled for prostate core biopsy or seeing their urologist for other conditions from 1997 through 1999 in Kingston, Ontario were eligible, excluding those with an earlier cancer. Age frequency matched controls (n=329) were compared with 79 incident prostate cancer cases. Before knowledge of diagnosis, the patients completed a questionnaire and donated 15 ml of blood for the measurement of 14 PCBs, and 13 organochlorine pesticides by gas chromatography. At least 70% of patients had detectable levels of nine PCB congeners and seven pesticides, and these chemicals were included in the risk analysis adjusted for total lipids. Geometric means for these PCB congeners, total PCBs, and p,p'-DDE are slightly lower for cases than controls, whereas the levels of p,p'-DDT and other pesticides are virtually equal. Adjusting for age and other confounders in multivariable logistic regression, odds ratios (ORs) are consistently below 1.0 for PCB congeners and total PCBs. For pesticides, most ORs are very close to the null. This study suggests that long-term low-level exposure to organochlorine pesticides and PCBs in the general population does not contribute to increased prostate cancer risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.