ArticleHeredity2009
Direct estimation of the mutation rate at dinucleotide microsatellite loci in Arabidopsis thaliana (Brassicaceae).
Article in Heredity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
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- Mutations of short tandem repeats explain abundant trait heritability in Arabidopsis.Genome biology · 2025Article
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- Impact of barriers on Cyrno-Sardinian endemisms: A comparative study of population genetics and phylogeography within taxa of Centranthus sect. Nervosae (Caprifoliaceae).Plant biology (Stuttgart, Germany) · 2025Article
- Unraveling historical genetic divergence and gene flow patterns between island (Taiwan) and mainland (China) ofFrontiers in plant science · 2025Article
- Fitness landscapes of human microsatellites.PLoS genetics · 2024Article
- Atlas of telomeric repeat diversity in Arabidopsis thaliana.Genome biology · 2024Article
- The vast majority of somatic mutations in plants are layer-specific.Genome biology · 2024Article
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- Genetic and demographic signatures accompanying the evolution of the selfing syndrome in Daphne kiusiana, an evergreen shrub.Annals of botany · 2023Article
- Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species.Journal of evolutionary biology · 2023Review
- Postglacial phylogeography, admixture, and evolution of red spruce (Frontiers in plant science · 2023Article
- Evolution of flowering time in a selfing annual plant: Roles of adaptation and genetic drift.Ecology and evolution · 2022Article
- Deforestation is the turning point for the spreading of a weedy epiphyte: an IBM approach.Scientific reports · 2021Article
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- Induced mutations alter patterns of quantitative variation, phenotypic integration, and plasticity to elevated COJournal of plant research · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The mutation rate at 54 perfect (uninterrupted) dinucleotide microsatellite loci is estimated by direct genotyping of 96 Arabidopsis thaliana mutation accumulation lines. The estimated rate differs significantly among motif types with the highest rate for AT repeats (2.03 x 10(-3) per allele per generation), intermediate for CT (3.31 x 10(-4)), and lowest for CA (4.96 x 10(-5)). The average mutation rate per generation for this sample of loci is 8.87 x 10(-4) (s.e.=2.57 x 10(-4)). There is a strong effect of initial repeat number, particularly for AT repeats, with mutation rate increasing with the length of the microsatellite locus in the progenitor line. Controlling for motif and initial repeat number, chromosome 4 exhibited an elevated mutation rate relative to other chromosomes. The great majority of mutations were gains or losses of a single repeat. Generally, the data are consistent with the stepwise mutation model of microsatellite evolution. Several lines exhibited multiple step changes from the progenitor sequence, but it is unclear whether these are multi-step mutations or multiple single-step mutations. A survey of dinucleotide repeats across the entire Arabidopsis genome indicates that AT repeats are most abundant, followed by CT, and CA.
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