Herpes simplex virus type 2: a key role in HIV incidence.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

52 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Effect of HSV-2 infection on subsequent HIV acquisition: an updated systematic review and meta-analysis.The Lancet. Infectious diseases · 2017
   Pooled it
2. The role of coinfections in HIV epidemic trajectory and positive prevention: a systematic review and meta-analysis.AIDS (London, England) · 2011
   Pooled it
3. Prevalent Herpes Simplex Virus-2 Increases the Risk of Incident Bacterial Vaginosis in Women from South Africa.AIDS and behavior · 2018
   Trial
4. Process Evaluation of a Clinical Trial to Test School Support as HIV Prevention Among Orphaned Adolescents in Western Kenya.Prevention science : the official journal of the Society for Prevention Research · 2017
   Trial
5. Biological factors that place women at risk for HIV: evidence from a large-scale clinical trial in Durban.BMC women's health · 2016
   Trial
6. Disclosure of HSV-2 serological test results in the context of an adolescent HIV prevention trial in Kenya.Sexually transmitted infections · 2015
   Trial
7. Tenofovir Gel for the Prevention of Herpes Simplex Virus Type 2 Infection.The New England journal of medicine · 2015
   Trial
8. Does offering human immunodeficiency virus testing at the time of blood donation reduce transfusion transmission risk and increase disclosure counseling? Results of a randomized controlled trial, São Paulo, Brazil.Transfusion · 2015
   Trial
9. Assessing the implementation effectiveness and safety of 1% tenofovir gel provision through family planning services in KwaZulu-Natal, South Africa: study protocol for an open-label randomized controlled trial.Trials · 2014
   Trial
10. Male circumcision significantly reduces prevalence and load of genital anaerobic bacteria.mBio · 2013
    Trial
11. Episodic therapy for genital herpes in sub-saharan Africa: a pooled analysis from three randomized controlled trials.PloS one · 2011
    Trial
12. Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.The New England journal of medicine · 2010
    Trial
13. Next Generation 3D Printed Multipurpose Intravaginal Ring For Sustained Co-Delivery of Antiretroviral Drugs and A Contraceptive Hormone.Pharmaceutical research · 2025
    Article
14. High Burden of Symptomatic and Asymptomatic Sexually Transmitted Infections in a Routine Decentralised HIV Care Setting in Eswatini: A Cross-Sectional Study.Tropical medicine & international health : TM & IH · 2025
    Article
15. Evaluation of the Sexually Transmitted Infections Programme among Key and Priority Populations in Primary Healthcare Facilities to Inform a Targeted Response: A Protocol Paper.Methods and protocols · 2024
    Article
16. Comparison of the Accuracy of HSV1 and HSV2 Antibody Tests with PCR in the Diagnosis of Recurrent Genital Herpes.Clinical, cosmetic and investigational dermatology · 2024
    Article
17. A pilot study to show that asymptomatic sexually transmitted infections alter the foreskin epithelial proteome.Frontiers in microbiology · 2022
    Article
18. A holistic perspective on herpes simplex virus (HSV) ecology and evolution.Advances in virus research · 2021
    Review
19. HIV prevalence by ethnic group covaries with prevalence of herpes simplex virus-2 and high-risk sex in Uganda: An ecological study.PloS one · 2018
    Article
20. Inferred father-to-son transmission of herpes simplex virus results in near-perfect preservation of viral genome identity and in vivo phenotypes.Scientific reports · 2017
    Article

Corrections and comments

• Comment on
  Incident HIV and herpes simplex virus type 2 infection among men in Rakai, Uganda.2009

Authors and funding

3 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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