ArticleJournal of endocrinological investigation2009
Growth hormone deficiency and antipituitary antibodies in a patient with common variable immunodeficiency.
Article in Journal of endocrinological investigation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- CVID Enteropathy Associated With Chronic Norovirus Infection: Background, Clinical Features, and Therapeutic Aspects.Reviews in medical virology · 2025Review
- The interplay of immunity and growth: a case of combined variable immunodeficiency and growth hormone deficiency.Annals of medicine and surgery (2012) · 2024Article
- Immune Dysregulation in Pediatric Common Variable Immunodeficiency: Implications for the Diagnostic Approach.Frontiers in pediatrics · 2022Article
- Common variable immune deficiency, central diabetes insipidus, and anemia.Central-European journal of immunology · 2020Article
- Endocrine Disorders Are Prominent Clinical Features in Patients With Primary Antibody Deficiencies.Frontiers in immunology · 2019Article
- Deficit of Anterior Pituitary Function and Variable Immune Deficiency Syndrome: A Novel Mutation.Global pediatric health · 2017Article
- Neurologic Complications of Common Variable Immunodeficiency.Journal of clinical immunology · 2016Article
- Autoimmune haematological disorders in two Italian children with Kabuki syndrome.Italian journal of pediatrics · 2014Article
- [Humoral immunodeficiency : awareness for better support].The Pan African medical journal · 2014Review
- Educational paper: primary antibody deficiencies.European journal of pediatrics · 2011Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Common variable immunodeficiency (CVID) is characterized by hypogammaglobulinemia and T-lymphocytes dysfunction. Autoimmune diseases are frequent. A 10.7-yr-old female, diagnosed with CVID when 7 yr old, was referred because of short stature. She was pre-pubertal and short (height -2.86 SD score) with delayed bone age. Her intestinal absorption, routine biochemistry, heart, renal, liver, and thyroid functions were normal. Two stimulation tests for GH showed a maximum peak of 1.9 ng/ml (IGF-1: 154 ng/ml, 147-832). When the patient was 13 yr old (height -4.23 SD score, telarche and pubarche stage 2, bone age 6.25 yr), GH treatment was initiated. Despite poor compliance, the growth velocity showed improvement. Anti-thyrogobulin, anti-thyroperoxidase, anti-21-hydroxylase, and anti-tyrosine-phosphate antibodies were negative while anti- pituitary antibodies (APA) were positive. For the first time, the presence of APA (previously associated with GH deficiency in non-CVID subjects) is reported in a CVID patient. The possibility of an autoimmune involvement of the pituitary gland was previously debated for CVID patients, but had never been demonstrated. This case suggests that in CVID, the pituitary gland can be targeted by autoantibodies and thus a more comprehensive follow-up of these patients should be performed.
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