ArticleThe Journal of biological chemistry2009
Heteromeric AtKC1{middle dot}AKT1 channels in Arabidopsis roots facilitate growth under K+-limiting conditions.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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63 citing papers in PubMed, 175 citations in OpenAlex.
- A Salt-ResponsiveInternational journal of molecular sciences · 2026Article
- Genome-wide identification of potassium transporters and channels in Malus domestica genome.Scientific reports · 2025Article
- Genome-Wide Identification and Expression Analysis of thePlants (Basel, Switzerland) · 2025Article
- The Potassium Utilization Gene Network inInternational journal of molecular sciences · 2025Article
- Potassium homeostasis and signalling: from the whole plant to the subcellular level.Quantitative plant biology · 2025Review
- Arabidopsis HAK5 under low KNature communications · 2024Article
- Research Progress on Plant Shaker KPlants (Basel, Switzerland) · 2024Review
- The role of CBL-CIPK signaling in plant responses to biotic and abiotic stresses.Plant molecular biology · 2024Review
- Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.Nature communications · 2022Article
- Overexpression of OsHAK5 potassium transporter enhances virus resistance in rice (Oryza sativa).Molecular plant pathology · 2022Article
- Non-autonomous stomatal control by pavement cell turgor via the K+ channel subunit AtKC1.The Plant cell · 2022Article
- Primary nutrient sensors in plants.iScience · 2022Review
- Identification and Characterization of Shaker KFrontiers in plant science · 2022Article
- Multiple ALMT subunits combine to form functional anion channels: A case study for rice ALMT7.Frontiers in plant science · 2022Article
- Sugar perception in honeybees.Frontiers in physiology · 2022Article
- Recent Advances in Genome-wide Analyses of Plant Potassium Transporter Families.Current genomics · 2021Review
- Adjustment of KInternational journal of molecular sciences · 2021Review
- Tri-SUS: a yeast split-ubiquitin assay to examine protein interactions governed by a third binding partner.Plant physiology · 2021Article
- Potential Networks of Nitrogen-Phosphorus-Potassium Channels and Transporters in Arabidopsis Roots at a Single Cell Resolution.Frontiers in plant science · 2021Article
- Global identification and characterization of miRNA family members responsive to potassium deprivation in wheat (Triticum aestivum L.).Scientific reports · 2020Article
3 more citing papers are in PubMed but not listed here.
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10 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant growth and development is driven by osmotic processes. Potassium represents the major osmotically active cation in plants cells. The uptake of this inorganic osmolyte from the soil in Arabidopsis involves a root K(+) uptake module consisting of the two K(+) channel alpha-subunits, AKT1 and AtKC1. AKT1-mediated potassium absorption from K(+)-depleted soil was shown to depend on the calcium-sensing proteins CBL1/9 and their interacting kinase CIPK23. Here we show that upon activation by the CBL.CIPK complex in low external potassium homomeric AKT1 channels open at voltages positive of E(K), a condition resulting in cellular K(+) leakage. Although at submillimolar external potassium an intrinsic K(+) sensor reduces AKT1 channel cord conductance, loss of cytosolic potassium is not completely abolished under these conditions. Depending on channel activity and the actual potassium gradients, this channel-mediated K(+) loss results in impaired plant growth in the atkc1 mutant. Incorporation of the AtKC1 subunit into the channel complex, however, modulates the properties of the K(+) uptake module to prevent K(+) loss. Upon assembly of AKT1 and AtKC1, the activation threshold of the root inward rectifier voltage gate is shifted negative by approximately -70 mV. Additionally, the channel conductance gains a hypersensitive K(+) dependence. Together, these two processes appear to represent a safety strategy preventing K(+) loss through the uptake channels under physiological conditions. Similar growth retardation phenotypes of akt1 and atkc1 loss-of-function mutants in response to limiting K(+) supply further support such functional interdependence of AKT1 and AtKC1. Taken together, these findings suggest an essential role of AtKC1-like subunits for root K(+) uptake and K(+) homeostasis when plants experience conditions of K(+) limitation.
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