ReviewMolecular cancer therapeutics2009
Regulated cell death pathways: new twists in modulation of BCL2 family function.
Review in Molecular cancer therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 93 citations in OpenAlex.
- Sperm abnormality: Differential expression of microRNAs.Journal of assisted reproduction and genetics · 2025Review
- Unlocking the diagnostic, prognostic roles, and immune implications of BAX gene expression in pan-cancer analysis.American journal of translational research · 2024Article
- FKBP8 variants are risk factors for spina bifida.Human molecular genetics · 2020Article
- Ailanthone Induces Cell Cycle Arrest and Apoptosis in Melanoma B16 and A375 Cells.Biomolecules · 2019Article
- The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma.BMC cancer · 2019Article
- Novel betulin derivative induces anti-proliferative activity by GOncology letters · 2018Article
- Crude Flavonoid Extract of Medicinal HerbOncology research · 2017Article
- Anti-proliferative Effects ofJournal of cancer prevention · 2017Article
- Pan-Cancer Analysis Links PARK2 to BCL-XL-Dependent Control of Apoptosis.Neoplasia (New York, N.Y.) · 2017Article
- Upregulation of Bcl-2 and Its Promoter Signals in CD4+ T Cells during Neuromyelitis Optica Remission.Frontiers in neuroscience · 2017Article
- Comparison of quartz vials with polypropylene vials for rapid cryopreservation of human ovarian tissue.Journal of ovarian research · 2016Article
- The hypoxia-mimetic agent CoCl₂ induces chemotherapy resistance in LOVO colorectal cancer cells.Molecular medicine reports · 2016Article
- Neuronal distress induced by low extracellular sodium in vitro is partially reverted by the return to normal sodium.Journal of endocrinological investigation · 2016Article
- The role of Six1 signaling in paclitaxel-dependent apoptosis in MCF-7 cell line.Bosnian journal of basic medical sciences · 2016Article
- ABT-737, a Bcl-2 Selective Inhibitor, and Chloroquine Synergistically Kill Renal Cancer Cells.Oncology research · 2016Article
- Ailanthone Inhibits Huh7 Cancer Cell Growth via Cell Cycle Arrest and Apoptosis In Vitro and In Vivo.Scientific reports · 2015Article
- NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells.Oncotarget · 2015Article
- TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells.Oncogene · 2015Article
- Time depended Bcl-2 inhibition might be useful for a targeted drug therapy.Cancer cell international · 2015Review
- The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
A number of cell death pathways have been recognized. Though apoptosis and autophagy have been well characterized, programmed necrosis has recently received attention and may provide clinical alternatives to suppress resistant tumors. Necrosis is primarily characterized by large-scale permeabilization, swelling, and rupture of cell membranes and the release of pro-inflammatory cytokines. Traditionally, necrosis in cancer cells has been indicative of poor prognoses, as chronic inflammation was found to encourage tumor growth. Yet, many antitumor effects associated with necrosis have been discovered in certain settings, such as the formation of an effective antitumor immune response. In this way, finding ways to attenuate the pro-tumor effects of necrosis while engaging the antitumor pathways via drugs, radiation, and sensitization may prove valuable as a clinical focus for the future. We hypothesize that the use of Bcl-2 inhibitors may enhance necrotic death characterized by inflammation and antitumor immunity. In this article, we briefly review apoptosis and autophagy and reason how necrosis may be a suitable alternative therapeutic endpoint. We then highlight novel inhibitors of Bcl-2 that may provide clinical application of our hypothesis in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.