Evidence map›Paper›PMID 19509056›Full record

ArticleJournal of cell science2009

Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.

Fiona E Hood, Stephen J Royle

Open access · greenAbstract read
In one paragraph

Article in Journal of cell science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  3. Coatopathies: Genetic Disorders of Protein Coats.Annual review of cell and developmental biology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Fiona E HoodThe Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, UK.
Stephen J Royle
University of Liverpool · GB

Funding

Cancer Research UK A8722
6 · The paper itself

Abstract

Clathrin is crucial for endocytosis and plays a recently described role in mitosis. Two clathrin heavy chains (CHCs) are found in humans: the ubiquitous CHC17, and CHC22, a CHC that is enriched in skeletal muscle. Functional differences have been proposed for these clathrins despite high sequence similarity. Here, we compared each paralogue in functional assays of endocytosis and mitosis. We find that CHC17 and CHC22 are functionally equivalent. We also describe how previous work on CHC22 has involved a splice variant that is not usually expressed in cells.

Indexed as

Cell LineClathrinClathrin Heavy ChainsEndocytosisHumansMitosisProtein IsoformsRecombinant Fusion ProteinsRNA InterferenceClathrinClathrin Heavy ChainsCLTCL1 protein, humanCLTC protein, humanProtein IsoformsRecombinant Fusion Proteins

Identifiers

PMID19509056
PMCPMC2821530
OpenAlexW2152089340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.